下面是引用scalpel于2005-12-10 09:17发表的:一个人带动一个学科此话当真不假至今山医妇产还是很有优势当然江森功亦不可没孔也算有所作为.......
陈搞生殖不错,不过山医妇产的传统在妇科手术学,这方面需要加油了。
陈教授的7篇英文文章
1: Fertil Steril. 2005 Nov;84(5):1553-1554.
Reply: Source of the extra pronucleus after ICSI.
Chen Z, Yan J, Feng HL.
Center for Human Reproduction, Shandong University and Shandong Provincial
Hospital, Jinan, China.
Publication Types:
LETTER
PMID: 16275272 [PubMed - as supplied by publisher]
2: Fertil Steril. 2005 Jun;83(6):1845-8.
Aneuploid analysis of tripronuclear zygotes derived from in vitro fertilization
and intracytoplasmic sperm injection in humans.
Chen Z, Yan J, Feng HL.
Center for Reproductive Medicine, Shandong Provincial Hospital, Shandong
University, Jinan, China.
This study demonstrates that the diploid ratio of tripronuclear zygotes after
intracytoplasmic sperm injection (ICSI) is significantly higher as compared with
that after conventional IVF; the extra pronucleus of tripronuclear zygotes after
ICSI are mostly from the second polar body, not from sperm.
PMID: 15950663 [PubMed - in process]
3: Int J Gynaecol Obstet. 2004 Sep;86(3):394-5.
Rupture of pregnancy in a communicating rudimentary uterine horn after in vitro
fertilization and embryo transfer.
Tang R, Sheng Y, Chen ZJ.
Department of Ob and Gyn, Reproductive Research Center, Shandong Provincial
Hospital, Shandong University, Jinan 250021, China.
Publication Types:
Case Reports
PMID: 15325862 [PubMed - indexed for MEDLINE]
4: Hum Reprod. 2004 Oct;19(10):2345-9. Epub 2004 Aug 6.
Effects of sucrose concentration on the developmental potential of human
frozen-thawed oocytes at different stages of maturity.
Chen ZJ, Li M, Li Y, Zhao LX, Tang R, Sheng Y, Gao X, Chang CH, Feng HL.
Center for Reproductive Medicine, Shandong Provincial Hospital, Shandong
University, Jinan 250021, China.
BACKGROUND: Success of human oocyte cryopreservation depends on multiple
cryobiological factors that could influence the developmental potential of the
oocytes. The objective of this study was to examine the effects of different
sucrose concentrations on the developmental potential of human frozen-thawed
oocytes at different maturity stages. METHODS: A total of 355 oocytes collected
from small follicles were randomly divided into three groups and two groups (B
and C) were cryopreserved using slow-freezing method. Group A included 131
oocytes at different maturity stages without freezing. Another 119 oocytes in
Group B were cryopreserved with 0.1 M sucrose and 105 oocytes in Group C with
0.2 M sucrose concentration. RESULTS: The post-thaw survival rate of the oocytes
and the cleavage rate in Group C were significantly higher than that of Group B
(P<0.05). For immature metaphase I (MI) stage oocytes, a significant difference
was found in the maturation rate between Group C and Group B (P<0.05). The
maturation rate for the GV oocytes in Groups A and C was significantly higher
than Group B (P<0.01). CONCLUSIONS: The results suggested that sucrose
concentration of 0.2 M in the cryoprotectant solution is more suitable for human
oocyte cryopreservation.
PMID: 15298975 [PubMed - indexed for MEDLINE]
5: J Pharm Pharmacol. 2003 Mar;55(3):353-8.
Quercetin, a phytoestrogen and dietary flavonoid, activates different
membrane-bound guanylate cyclase isoforms in LLC-PK1 and PC12 cells.
Chen ZJ, Vetter M, Chang GD, Liu S, Chang CH.
Department of Medicine, Reproductive Research Center, Shandong Provincial
Hospital, Shandong University, Jinan, P. R. China.
Accumulated evidence suggests that quercetin, a dietary flavonoid, has
beneficial effects in protection against cardiovascular diseases and in the
inhibition of tumour growth. We have recently shown that antioxidants such as
17beta-estradiol, resveratrol, dithiothreitol and vitamin C activate
membrane-bound guanylate cyclase GC-A, a receptor for atrial natriuretic factor
(ANF). Since quercetin is a phytoestrogen and potent antioxidant, it is possible
that it may activate GC-A or other guanylate cyclase isoforms. We examined
whether quercetin activates GC-A or GC-B (the receptor for C-type natriuretic
peptide, CNP) in PC12 and porcine kidney proximal tubular LLC-PK1 cells. The
results showed that quercetin activated a guanylate cyclase isoform in both cell
types. Quercetin inhibited CNP-stimulated GC-B activity, but had little effect
on ANF-stimulated GC-A activity in PC12 cells, suggesting that quercetin mainly
activates GC-B in PC12 cells. In contrast, CNP had no effect on guanylate
cyclase activity in LLC-PK1 cells, indicating that GC-B is not expressed in
LLC-PK1 cells. Furthermore, quercetin had a small effect on ANF-stimulated GC-A
activity and had no effect on soluble guanylate cyclase activity in LLC-PK1
cells, suggesting that quercetin does not activate GC-A, GC-B or soluble
guanylate cyclase in LLC-PK1 cells. However, quercetin did stimulate
membrane-bound guanylate cyclase activity in LLC-PK1 cell membranes. These
results indicate that quercetin activates the GC-B isoform in PC12 cells, but
activates an unknown membrane-bound guanylate cyclase isoform in LLC-PK1 cells.
PMID: 12724041 [PubMed - indexed for MEDLINE]
6: J Pharm Pharmacol. 2001 Feb;53(2):243-7.
Antioxidants, vitamin C and dithiothreitol, activate membrane-bound guanylate
cyclase in PC12 cells.
Chen ZJ, Che D, Chang CH.
Department of Medicine, Reproductive Research Center, Shandong Provincial
Hospital, Shandong Medical University, Jinan, Peoples Republic of China.
Antioxidants and antioxidant enzymes are known to protect against cell death
induced by reactive oxygen species. However, apart from directly quenching free
radicals, little is known about the effect of antioxidants on hormone-activated
second messenger systems. We previously found that antioxidants such as 17-beta
estradiol and resveratrol activate membrane-bound guanylate cyclase GC-A, the
receptor for atrial natriuretic factor (ANF), in PC12 cells. It is possible that
other antioxidants may also activate membrane-bound guanylate cyclase GC-A. The
aim of this study was to determine if dithiothreitol (DTT), vitamin C, and
vitamin E activate membrane-bound guanylate cyclase GC-A in PC12 cells. The
results showed that both DTT and vitamin C increased cGMP levels in PC12 cells,
whereas vitamin E had no effect. DTT and vitamin C inhibited membrane-bound
guanylate cyclase activity stimulated by ANF in PC12 cells. In contrast, DTT and
vitamin C had no effect on soluble guanylate cyclase activity stimulated by
substance P. Furthermore, NO synthase inhibitors L-NAME and aminoguanidine did
not affect DTT- and vitamin C-stimulated guanylate cyclase activity. The results
indicate that DTT and vitamin C, but not vitamin E, activate membrane-bound
guanylate cyclase GC-A in PC12 cells.
PMID: 11273022 [PubMed - indexed for MEDLINE]
7: Chin Med J (Engl). 1992 Sep;105(9):785-7.
Delivery by direct intrauterine transfer of gametes.
Su YK, Chen ZJ, Feng Y, Liu LK, Li JJ, Liu XM.
Department of Obstetrics and Gynecology, Shandong Provincial Hospital, Jinan.
A nurse, 27, primary sterility for 5 years, had normal menstruation, normal size
of uterus anterior. HSG: Rt. tube was not visible, Lt. tube slightly enlarged at
ampulla. Ovaries were over-stimulated by clomiphene, HMG and hCG.8 ova were
taken through vaginal aspiration under B-mode ultrasound scanning. Direct
introduction of ova and washed sperms simultaneously into the uterus on Sept.
19, 1991 resulted in successful single pregnancy up to 36(+1) weeks. A 2 250 g
normal baby boy was delivered on May 15, 1992 spontaneously. The base and
prospect of this manoeuver are discussed with a reference to Craft's procedure.
PMID: 1288984 [PubMed - indexed for MEDLINE]