陈春燕论文被评为06年山东省优秀博士论文 [复制链接]

陈春燕论文被评为06年山东省优秀博士论文


2006-09-05 15:52
　　
  〔本站讯〕近日，在第七次山东省优秀博士、硕士学位论文通讯评议和会议评审中，山大第二医院有一篇论文被评为山东省优秀博士学位论文。
  此次评审共评出优秀博士学位论文30篇、优秀硕士学位论文70篇。第二医院陈春燕教授的学位论文《白血病比较蛋白质组学和CpG基序生物学效应的初步研究》获2006年省优秀博士学位论文奖。
  陈春燕教授是2004届血液病学专业科学学位博士研究生，获奖论文由第二医院血液内科博士生导师潘祥林教授指导。

{作者:李青 张瑞雪 来自:第二医院 编辑:新闻中心总编室 责任编辑:马龙}

1: Chin J Physiol. 2006 Feb 28;49(1):31-8.

Erratum in:
  Chin J Physiol. 2006 Apr 30;49(2):117.

Comparative proteomics of apoptosis initiation induced by 5-fluorouracil in
human gastric cancer.

Chen CY, Jia JH, Zhang MX, Zhou YB, Zhang RM, Yu XP.

Department of Microbiology, School of Medicine, Shandong University, Jinan
250012, Shandong, PR China.

5-Fluorouracil is the first choice chemotherapeutic drug for patients with
gastric cancer, but the mechanism that 5-fluorouracil plays the anti-tumor role
remains unclear. The aim of this study was to clarify correlated [corrected]
proteins induced by 5-fluorouracil in the apoptosis-initiation of human gastric
cancer (MGC-803) cells. The time point of apoptosis-initiation induced by
5-fluorouracil in MGC-803 cells was determinated using
5-fluorouracil-withdrawal. Two-dimensional electrophoreses (2-DE) were employed
to compare the differentials of protein expressions of the MGC-803 cells at the
apoptosis-initiation phase and those of the MGC-803 cells untreated with
5-fluorouracil. The differential proteins included 14 upregulated proteins and 8
downregulated proteins. They indicated a more-than-doubled alteration. These
proteins were digested in gels by trypsin and the mass of generated peptides
were measured by matrix assisted laser desorption ionization time of flight mass
spectrometry (MALDI-TOF-MS). The data obtained from peptide mass fingerprinting
(PMF) were searched out using the internet available database mascot
(http://www.matrixscience.com). The results showed that proteomics analyses have
evidenced that many kinds of proteins are involved in the apoptosis initiation
of human gastric cancer MGC-803 cells. These proteins are related to metabolism,
oxidation, cytoskeleton and signal transduction and other aspects of cells. In
conclusion, the experiment model of apoptosis-initiation of human gastric cancer
MGC-803 cells induced by 5-fluorouracil based on proteomic analysis has been
established, giving an impetus to researches of the mechanism of apoptosis in
human gastric cancer, and laying a foundation for the selection of potential
drug precursors specific for inducing apoptosis-initiation in human gastric
cancer.

PMID: 16900703 [PubMed - indexed for MEDLINE]

2: Zhonghua Xue Ye Xue Za Zhi. 2004 Jan;25(1):13-6.

[Study of antileukemic effect of CpG-oligodeoxynucleotides treated cord blood]

[Article in Chinese]

Chen CY, Jia JH, Pan XL, Zhou YB, Zhao WM.

Department of Hematology and Oncology, the Second Hospital of Shandong
University, Jinan 250033, China.

OBJECTIVE: To observe the antileukemic effect of lymphocytes from cord blood
treated by CpG-oligodeoxynucleotides (CpG-ODN). METHODS: Lymphocytes from cord
blood were exposed to different oligodeoxynucleotides containing a panel of
CpG-ODN and were cultured with K562 cells. The cytotoxic effects were detected
by MTT method. Immunological markers of cord blood treated by CpG-ODN(3) which
showed highest activity were measured with flow cytometry. RESULTS: Different
CpG-motifs have different immunostimulatory activity and CpG-ODN(3) has the
highest one. After treated by CpG-ODN(3), NK killing activity to K562 cells
increased in a dose-dependent manner, and CD(3), CD(4), CD(19) and CD(56)
increased to (60.6 +/- 7.9)%, (40.2 +/- 3.5)%, (22.4 +/- 1.9)% and (15.5 +/-
3.1)%, respectively. CONCLUSION: CpG-ODN could reinforces the immunological
competence of cord blood lymphocytes and their effects on K562 cells. This
provides a new approach to reinforce the antitumor effects of cord blood.

PMID: 14990069 [PubMed - indexed for MEDLINE]

3: Zhonghua Xue Ye Xue Za Zhi. 2003 Dec;24(12):624-8.

[Comparative proteomics research of apoptosis initiation induced by
homoharringtonine in HL-60 cells]

[Article in Chinese]

Chen CY, Jia JH, Pan XL, Meng YS, Tu ZH.

Department of Hematological Malignancy, the Second Hospital of Shandong
University, Jinan 250033, China.

OBJECTIVE: To study the related proteins of apoptosis initiation induced by
homoharringtonine (HHT) in HL-60 cells. METHODS: After establishment of an
apoptosis initiation model induced by HHT in HL-60 cells, proteins of untreated
and HHT treated HL-60 cells were extracted, and the two-dimensional
polyacrylamide gel electrophoresis (2-DE) maps of the extracted proteins were
established by using the immobilized pH gradient (IPG) two-dimensional
electrophoresis respectively. The alteration protein spots were identified with
assisted laser desorption ionization time-of-flight mass spectrometry
(MALDI-TOF-MS) and database searching. RESULTS: Proteomics analysis showed that
proteins including MHC class I antigen, calbindin D-28K, chloride channel
protein 6, oncoprotein 18, zinc finger protein Helios and apoptosis inhibitor
like protein 2 were involved in apoptosis initiation induced by HHT. CONCLUSION:
The present study might conduce to the researches of HL-60 cells carcinogenesis
and pave the way to exploit drug precursor related to HHT and initiation of
apoptosis in HL-60 cells.

PMID: 14761608 [PubMed - indexed for MEDLINE]

恭喜
努力~

ok ok

引用第1楼merck于2006-09-09 11:05发表的“”:1: Chin J Physiol. 2006 Feb 28;49(1):31-8. Erratum in:   Chin J Physiol. 2006 Apr 30;49(2):117........

Merck
想请教
形如这样的可以搜到摘要的都是ＳＣＩ吗？

谢谢

引用第4楼dsdsds于2006-09-14 23:39发表的“”:Merck想请教形如这样的可以搜到摘要的都是ＳＣＩ吗？.......

当然不是了，这种在PUBMED搜到摘要的杂志都是被MEDLINE收录的杂志，所以只能说文章被MEDLINE收录。

那本Chinese Journal of Phsiology是海峡对面台湾省的“中国生理学会”主办的杂志，是被SCI收录的杂志，所以这篇文章是被SCI收录的。
所以，文章想被SCI收录，所发表的期刊首先要被SCI收录。
后面量篇中文文章是大陆中文杂志，没有被SCI收录。中华系列杂志只有《Chinese Medical Journal》（《中华医学杂志》英文版）被SCI收录。其他包括中华医学杂志，中华内科，中华外科，中华妇产科等等都不被SCI收录。