其实心血管专业里面JACC更接近临床，今年大陆有2篇。
1:上海泽生科技周明东
J Am Coll Cardiol. 2006 Oct 3;48(7):1438-47. Epub 2006 Sep 14.
Comment in:
J Am Coll Cardiol. 2006 Oct 3;48(7):1448-50.
Neuregulin-1/erbB-activation improves cardiac function and survival in models of
ischemic, dilated, and viral cardiomyopathy.
Liu X, Gu X, Li Z, Li X, Li H, Chang J, Chen P, Jin J, Xi B, Chen D, Lai D,
Graham RM, Zhou M.
Zensun Sci & Tech Ltd., Shanghai, China.
OBJECTIVES: We evaluated the therapeutic potential of a recombinant 61-residue
neuregulin-1 (beta2a isoform) receptor-active peptide (rhNRG-1) in multiple
animal models of heart disease. BACKGROUND: Activation of the erbB family of
receptor tyrosine kinases by rhNRG-1 could provide a treatment option for heart
failure, because neuregulin-stimulated erbB2/erbB4 heterodimerization is not
only critical for myocardium formation in early heart development but prevents
severe dysfunction of the adult heart and premature death. Disabled
erbB-signaling is also implicated in the transition from compensatory
hypertrophy to failure, whereas erbB receptor-activation promotes myocardial
cell growth and survival and protects against anthracycline-induced
cardiomyopathy. METHODS: rhNRG-1 was administered IV to animal models of
ischemic, dilated, and viral cardiomyopathy, and cardiac function and survival
were evaluated. RESULTS: Short-term intravenous administration of rhNRG-1 to
normal dogs and rats did not alter hemodynamics or cardiac contractility. In
contrast, rhNRG-1 improved cardiac performance, attenuated pathological changes,
and prolonged survival in rodent models of ischemic, dilated, and viral
cardiomyopathy, with the survival benefits in the ischemic model being additive
to those of angiotensin-converting enzyme inhibitor therapy. In addition,
despite continued pacing, rhNRG-1 produced global improvements in cardiac
function in a canine model of pacing-induced heart failure. CONCLUSIONS: These
beneficial effects make rhNRG-1 promising as a broad-spectrum therapeutic for
the treatment of heart failure due to a variety of common cardiac diseases.
PMID: 17010808 [PubMed - indexed for MEDLINE]
2: 解放军总医院老年医学研究所何耀
J Am Coll Cardiol. 2006 Apr 18;47(8):1588-94. Epub 2006 Mar 29.
Prevalence of the metabolic syndrome and its relation to cardiovascular disease
in an elderly Chinese population.
He Y, Jiang B, Wang J, Feng K, Chang Q, Fan L, Li X, Hu FB.
Institute of Geriatrics, Chinese PLA General Hospital, Beijing, China.
yhe301@x263.netOBJECTIVES: This study sought to assess the prevalence of the metabolic syndrome
(MetS) and its association with cardiovascular disease (CVD) in elderly Chinese
people. BACKGROUND: The information available about the prevalence of MetS based
on the National Cholesterol Education Program (NCEP) and the International
Diabetes Federation (IDF) in China is limited. METHODS: We conducted a
population-based cross-sectional study in an urban Beijing sample of 2,334
participants age 60 to 95 years (943 men, 1,391 women). The CVD included
diagnosed coronary heart disease (CHD), stroke, and peripheral arterial disease
(PAD). RESULTS: The prevalence of MetS by the NCEP criteria was 30.5% (17.6% in
men, 39.2% in women). Use of the new IDF definition significantly increased the
prevalence to 46.3% (34.8% in men, 54.1% in women). Odds ratios (OR) for CHD,
stroke, PAD, and CVD in those with MetS using the NCEP criteria were 1.43 (95%
confidence interval [CI] 1.18 to 1.74), 1.45 (95% CI 1.14 to 1.85), 1.47 (95% CI
1.18 to 1.84), and 1.50 (95% CI 1.25 to 1.81), respectively. Corresponding ORs
using new IDF criteria were 1.69 (95% CI 1.40 to 2.02), 1.58 (95% CI 1.26 to
2.00), 1.42 (95% CI 1.14 to 1.76), and 1.73 (95% CI 1.46 to 2.07), respectively.
Those who met the IDF but not the NCEP criteria (n = 436, 18.7%) had
significantly elevated ORs for CHD (1.66, 95% CI 1.31 to 2.10) and stroke (1.53,
95% CI 1.13 to 2.06). CONCLUSIONS: The MetS is highly prevalent in elderly
people in Beijing, particularly among women. Individuals with MetS defined by
either criteria are at significantly elevated ORs for CHD, stroke, and PAD. The
IDF criteria seem to be better suited than the NCEP criteria for screening and
estimating risk of MetS in Chinese people.
PMID: 16630995 [PubMed - indexed for MEDLINE]
