1 【题名】：SHORT IN VITRO HALF-LIFE OF THYMOPOIETIN 32–36 PENTAPEPTIDE IN HUMAN PLASMA
【作者】：Tischio JP, Patrick JE, Weintraub HS, Chasin M, Goldstein G.
【杂志名全称】：Int J Pept Protein Res.
【年, 卷(期), 起止页码】：1979;14(5):479-84.
【全文链接】：
http://www3.interscience.wiley.com/journal/121592690/abstract?CRETRY=1&SRETRY=0 【摘要信息】：Thymopoietin32--36 (TP5) is a synthetic pentapeptide that has the biological activity of its parent molecule, the 49 amino acid thymic hormone thymopoietin. Tritiated thymopoietin32--36 (3 /-TP5) was prepared by reductive tritiation of dibromotyrosyl-TP5. The stability of 3 H-TP5 in human plasma was studied by analyzing samples by thin-layer chromatography at different time points and quantitating the radioactivity associated with TP5 (Arg-Lys-Asp-Val-Tyr) and its tyrosyl-containing breakdown products (Lys-Asp-Val-Tyr, Asp-Val-Tyr, Val-Tyr, Tyr). In plasma (but not in saline) the pentapeptide was rapidly degraded (apparent t1/2 approximately 30 seconds) with the corresponding appearance of radioactivity associated with the other tyrosyl-containing reference compounds. These data imply that the pentapeptide, which is active in vivo, may rapidly trigger changes in responsive cells; sustained circulating levels may not be required for activity
2 【题名】：Aspects of the immunopharmacology of thymosin α1
【作者】：John W Hadden,
【杂志名全称】：Clin Appl Rev,
【年, 卷(期), 起止页码】： 2001, 1(3): 187-191.
【全文链接】：
http://www.clinappliedimmun.com/article/S1529-1049(01)00012-5/abstract
【摘要信息】：
In this report some of the salient features of thymosin-α1's immunopharmacology are summarized. Our studies have shown that therapy using IRX-3 (a combination of thymosin-α1 with IRX-2—natural cytokine mixture) produced more dramatic effects than either alone in reversing immunodeficiency in aged mice. If these effects translate into the human, we would anticipate that we would observe correction of T lymphocytopenia and to do so at least in part by promoting development and exodus from the thymus of recent thymic emigrees. We expect that IRX-3 will find use in a variety of conditions associated with cellular immune deficiency including infections and cancer.
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