1。Zhonghua Nei Ke Za Zhi. 2010 Jul;49(7):558-9.
[Acute kidney injury: an overlooked aetiology of end-stage renal disease].
[Article in Chinese]
Wang J, Chen N.
PMID: 20979762 [PubMed - in process]
有中文版的更好
2。Clin Nephrol. 2010 Sup;74(S1):89-94.
Acute kidney injury as a risk factor for chronic kidney diseases in disadvantaged populations.
Liaño F, Tenorio MT, Rodriguez-Mendiola N, Ponte B.
1Department of Nephrology, Hospital Universitario Ramon y Cajal, 2Consorcio de Investigacion del Fracaso Renal Agudo (CIFRA), Comunidad de Madrid, 3Department of Medicine, Alcala University School of Medicine, Alcala de Henares, Madrid, Spain and 4Department of Nephrology, University Hospital of Geneva, Switzerland (present address).
Abstract
Acute kidney injury (AKI) is considered to be a potential cause for developing chronic kidney disease (CKD); on the other hand, CKD predisposes to AKI. The lack of adequate epidemiological data makes it difficult to determine if AKI induces CKD in less developed countries. The etiology of AKI in rich populations, in whom sophisticated surgery, interventional radiology and oncology treatments are usually the cause of AKI, is very different from that of disadvantaged populations, where the origin of AKI is associated with endemic infections, obstetric problems, poisons, toxins and natural disasters. Any conclusions extrapolated from these two settings should be treated with caution. Moreover, people living in disadvantaged conditions are usually much younger than those in rich areas and this age factor could facilitate total recovery of renal function after AKI if treatment based on an adequate supply of water, rehydration and anti-infectious measures were provided. In the small segment of the population of less developed countries having an income per capita similar to that observed in the developed countries, the long-term outcome of AKI should also be expected to be similar. New data coming from two single centers analyzing only the long-term outcome of acute tubular necrosis (ATN) patients, with a normal or near normal renal function prior to the AKI episode, coincide in reporting a requirement for chronic dialysis among the surviving patients of 2%. If these data are confirmed, the importance of AKI as cause of CKD should be reconsidered, both in developed and less developed countries.
PMID: 20979971 [PubMed - as supplied by publisher]
谢谢各位高手
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