基础导师简介
高成江 博士 山东省泰山学者，教授，博士生导师 Phone ： 0531-88382292 ， Fax ： 0531-88382292 E-mail ： cgao@sdu.edu.cn 个人简介： 男， 1971 年 8 月生， 1995 年毕业于山东大学生物系获学士学位， 2000 年毕业于中国科学院上海植物生理研究所获博士学位， 2001 年至 2007 年先后在加州大学、杜克大学进行博士后研究， 2007 年至今在山东大学医学院工作， 2007 年入选山东省 “ 泰山学者 ” 。
学习和工作经历： 2007.10- 至今 山东省泰山学者特聘教授
2007.10- 至今 山东大学医学院 教授、博士生导师
2002.08-2007.10 美国杜克大学医学院 Research Associate
2001.02-2002.08 美国加州大学戴维斯分校 博士后
1995.09-2000.12 中国科学院上海植物生理研究所 博士
1991.09-1995.07 山东大学生物系 学士
研究领域 ： 本试验室利用分子生物学、免疫学和生物化学等学科专业知识，并结合动物模型，在分子水平和细胞水平，研究败血症 (Sepsis) ，炎症 (Inflammation) 及肿瘤免疫 (Tumor immunology) 的分子生物学机制；具体研究内容包括真核基因的转录表达调控、蛋白质的转译后修饰、宿主与病原微生物的相互作用以及一氧化氮（ NO ）的信号传导。
近期 SCI 论文： ．
Gao Chengjiang , Guo H, Mi Z, Grusby M, Kuo PC. Osteopontin Induces Ubiquitin-Dependent Degradation of STAT 1 in RAW264.7 Murine Macrophages. J Immunol. 2007, 178(3):1870-81.
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Gao Chengjiang , Guo H, Mi Z, Wai P, Kuo PC. Transcriptional regulatory functions of heterogeneous nuclear ribonucleoprotein-u and -a/b in endotoxin-mediated macrophage expression of osteopontin. J Immunol. 2005, 175(1):523-30.
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Gao Chengjiang , Guo H, Wei J, Mi Z, Wai P, Kuo PC. S-nitrosylation of hnRNP- A/B regulates osteopontin transcription in endotoxin-stimulated murine macrophages. J Biol Chem. 2004, 279(12): 11236-43.
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Gao Chengjiang , Mi Z, Guo H, Kuo PC. Osteopontin Regulates Ubiquitin-Dependent Degradation of Stat 1 In Murine Mammary Epithelial Tumor Cells. Neoplasia. 2007, 9(9):699-706.
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Gao Chengjiang , Guo H, Downey L, Marroquin C, Wei J, Kuo PC. Osteopontin-dependent CD44v6 expression and cell adhesion in HepG2 cells. Carcinogenesis 2003, 24(12): 1871-1878.
． *
Gao Chengjiang , Guo H, Wei J, Mi Z, Wai P, Kuo PC. Identification of S-nitrosylated proteins in endotoxin-stimulated RAW 264.7 murine macrophage. Nitric Oxide: Biology and Chemistry. 2005, 12(2):121-6. *One of the top 5 downloaded papers of Nitric Oxide in 2005
． Gao Chengjiang , Mi Z, Guo H, Wei J, Wai P, Kuo P C. A transcriptional repressor of osteopontin expression in the 4T1 murine breast cancer cell line. Biochem Biophys Res Commun. 2004, 321(4): 1010-6.
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Gao Chengjiang , Guo H, Wei J, Kuo PC. Osteopontin inhibits expression of cytochrome c oxidase in RAW 264.7 murine macrophages. Biochem Biophys Res Commun. 2003, 309(1): 120-5.
． Guo H, Wai PY, Mi Z, Gao Chengjiang , Zhang J, Kuo PC. Osteopontin mediates Stat1 degradation to inhibit iNOS transcription in a cecal ligation and puncture model of sepsis. Surgery 2008, in press.
． Guo H,
Gao Chengjiang , Mi Z, Zhang J, Kuo PC. Characterization of the PC4 binding domain and its interactions with HNF4alpha. J Biochem. 2007, 141(5):635-40.
． Guo H,
Gao Chengjiang , Mi Z, Wai P, Kuo PC. Phosphorylation of serine-158 regulates inflammatory redox dependent hepatocyte nuclear factor 4alpha transcriptional activity. Biochem J. 2006, 394(Pt 2):379-87.
． Takami Y , Russell MB ,
Gao Chengjiang , Mi Z , Guo H , Mantyh CR , Kuo PC . Sp1 regulates osteopontin expression in SW480 human colon adenocarcinoma cells. Surgery. 2007, 142(2):163-9.
． Guo L , Guo H ,
Gao Chengjiang , Mi Z , Russell WB , Kuo PC . Stat1 acetylation inhibits inducible nitric oxide synthase expression in interferon-gamma-treated RAW264.7 murine macrophages. Surgery. 2007, 142(2):156-62.
． Wai PY, Guo L,
Gao Chengjiang , Mi Z, Guo H, Kuo PC. Osteopontin inhibits macrophage nitric oxide synthesis to enhance tumor proliferation. Surgery 2006, 140(2):132-40.
． Wai PY, Mi Z,
Gao Chengjiang , Guo H, Marroquin C, Kuo PC. Ets-1 and runx2 regulate transcription of a metastatic gene, osteopontin, in murine colorectal cancer cells. J Biol Chem. 2006, 281(28):18973-82.
． Wei J, Guo H,
Gao Chengjiang , Kuo PC. Peroxide-mediated chromatin remodelling of a nuclear factor kappaB site in the mouse inducible nitric oxide synthase promoter. Biochem J. 2004, 377(Pt 3): 809-18.
． Mi Z, Oliver T, Guo H,
Gao Chengjiang , Kuo PC. Thrombin-cleaved COOH(-) terminal osteopontin peptide binds with cyclophilin C to CD 147 in murine breast cancer cells. Cancer Res. 2007, 67(9):4088-97.
． Mi Z , Guo H , Wai PY ,
Gao Chengjiang , Kuo PC . Integrin-linked kinase regulates osteopontin-dependent MMP-2 and uPA expression to convey metastatic function in murine mammary epithelial cancer cells. Carcinogenesis. 2006, 27(6):1134-45.
． Mi Z , Guo H , Wai PY ,
Gao Chengjiang , Wei J , Kuo PC . Differential osteopontin expression in phenotypically distinct subclones of murine breast cancer cells mediates metastatic behavior. J Biol Chem. 2004, 279(45):46659-67.
． Wai PY, Mi Z, Guo H, Sarraf-Yazdi S,
Gao Chengjiang , Wei J, Marroquin CE, Clary B, Kuo PC. Osteopontin silencing by small interfering RNA suppresses in vitro and in vivo CT26 murine colon adenocarinoma metastasis. Carcinogenesis 2005, 26:741-51.
科研项目和科研经费： 山东省 “ 泰山学者 ” 启动经费 200 万元本专业毕业生可在高校从事科研和教学工作，也有很多机会到国外进修和学习。 2009 年拟招收博士生 2-3 名，欢迎有志者踊跃报名。
