The final examination of medical immunology
for seven year students of Grade 2003(2005/12/6)
I. Explain the following items (2 points for each, 18 points)
1. Lymphocyte recirculation
2. CDR
3. cytokine
4. MHC restriction
5. PRR
6. Immune tolerance
7. ITAM
8.APC
9. TI-Ag
II. Choose all correct answers (1 point for each,15 points)
1. Which of the following statement(s) about the spleen is(are) true:
A. It filters antigens out of the blood.
B. Lymphatic vessels draining the tissue spaces enter the spleen
C. It contains germinal centers
D. It functions to remove old and defective red blood cells
2.Which kinds of Ig expressed mainly on the surface of mature B cells?
A. mIgG B. mIg A C. mIgD D.mIgM
3.Which can function as C3 convertase in activation of complement system?
A.C4b2b B.C4b2b3b C.C3bBb D.C3bnBb
4.About the characteristics of cytokines, which of the following(s) is (are) correct?
A. One cytokine can act on different cells and play multiple biological effects
B. The cytokine produced by one cell only acts on neighbor cells
C. Combined with corresponding receptor to play role
D. One cytokine can inhibit or enhance effects of other cytokine
5.Which of the following molecules can stimulate T cells activation?
A. LPS B. PWM C. Con A D. PHA
6.What are the functions of B cells?
A. produce Ab
B. secrete cytokines
C. kill target cells directly
D. present Ag
7.Which of the cytokines are secreted by Th1 cells?
A. IL-4 B. IL-2 C. IL-10 D. IFN-γ
8.Which of the diseases belong to type Ⅲ hypersensitivity?
A. Transfusion reaction
B. Arthus reaction
C. Contact dermatitis
D. Rheumatoid arthritis
9.Which of the following is(are) correct about the characteristics of memory cells?
A. Can come from either B cell or T cell
B. Can respond to antigen at low consentrate effectivelly
C. Only exist in HI
D. React to a second invasion of an antigen more rapidly and stronger
10.What abilities do αβ+T cells gain after maturation?
A. self-reactive
B. self-tolerance
C. express functional TCR
D. self MHC restriction
11.Which of the followings are correct statements about dendritic cells?
A. Can stimulate naïve T cell proliferation
B. Express high level of MHC class II molecules
C. Express high level of MHC class I molecules
D. Mature dendritic cells with strong function of antigen-capture
12.About AICD, which statements are correct?
A. Can be mediated by FasL-Fas interaction
B. Is a kind of cell death of activated T cell
C. Play important roles in immunological regulation
D. IL-4 can promote AICD
13. The processes of antigen-activated B cells differentiation in germinal center include:
A. Ig Class switching
B. Somatic hypermutation and Ig affinity maturation
C. Differentiate into Bm
D. Apoptosis
14.Which of the following factors affect the antigen immunogenecity?
A. molecule weight B. foreigness
C. conformation D. chemical composition
15. About somatic hypermutation, which statements are correct?
A. Occurs during B cells maturation
B. Result in affinity maturation of antibodies
C. Mainly occurs in CDR region
D. Can occur during T cells maturation
Ⅲ．Answer the following questions briefly (5 point for each, 30 points)
1. How can T helper cells play important roles in an antibody mediated response.
2.What cells express the HLA II molecules? What are the functions of HLA II molecules on these cells?
3.If we want to label the antibody with enzyme for ELISA experiment, what part of antibody does enzyme should bind to? Why?
4.How do effector specific CTLs kill tumor cells? What are the characteristics for this process?
5. How are endogenous antigens recognized by CD8+ T cells?
6. What is Neonate hemolysis? Please describe its mechanism.
IV. Answer following question (12 points)
1. How the innate and adaptive immunity act in cooperative and inter-dependent ways to protect the host.?
