1: Chin Med J (Engl). 2006 Mar 5;119(5):422-5.
Inducing apoptosis and upregulation of Bax and Fas ligand expression by allicin
in hepatocellular carcinoma in Balb/c nude mice.
Zhang ZM, Zhong N, Gao HQ, Zhang SZ, Wei Y, Xin H, Mei X, Hou HS, Lin XY, Shi Q.
Health Examination Center Qilu Hospital of Shandong University, Jinan 250012,
China.
sdmalei@126.comPMID: 16542588 [PubMed - indexed for MEDLINE]
2: Chin Med J (Engl). 2006 Mar 5;119(5):403-7.
Transanal, single stage, endorectal pull through for Hirschsprung's disease in
China: a collective review.
Li AW, Zhang WT.
Department of Pediatric Surgery, Qilu Hospital, Shandong University, Jinan
250012, China.
liaiwuxie@yahoo.com.cnPublication Types:
Review
PMID: 16542584 [PubMed - indexed for MEDLINE]
3: Chin Med J (Engl). 2006 Feb 5;119(3):179-84.
Comparison of the veracity of real-time perfusion, harmonic angio, and
ultraharmonic mocardial contrast imaging modes in evaluation of acute myocardial
infarction area.
Xing YQ, Zhang Y, Li DQ, Liu XQ, Li XQ, Zhao CQ, Chen M, Gao HQ.
Cardiology Unit of Senior Care Department, Qilu Hospital, Shandong University,
Ji'nan 250012, China.
xingyanqiu@sina.comBACKGROUND: Innovative advancements in ultrasound instrumentation present a
number of imaging modalities for myocardial contrast echocardiography (MCE) in
ischemic syndromes. How well they compare to each other in diagnostic accuracy
in the detection of acute myocardial infarction is unclear. The purpose of this
study was to assess the relative accuracy of 3 different imaging modes of MCE,
low mechanical index (MI) real-time perfusion imaging (RTPI), triggered harmonic
angio mode (HA), and ultraharmonic imaging mode (UH) in the detection of acute
experimental myocardial infarction within the time frame suitable for potential
reperfusion. METHODS: MCE was performed in 10 open-chest dogs using RTPI,
triggered HA and triggered UH modes at baseline and one hour after occlusion of
left anterior descending coronary artery. Presence or absence of perfusion
defects, and the perfusion defect size when present, were analyzed and compared
with the infarct size delineated by triphenyltetrazolium chloride (TTC)
staining. RESULTS: The infarct area was (15.8 +/- 2.4)% by TTC staining;
Perfusion defect area by MCE was similar to anatomic infarct area in all the
three MCE approaches: (16.1 +/- 2.7)% by RTPI mode, (15.5 +/- 2.9)% by HA mode,
and (15.5 +/- 3.0)% by UH mode. The sensitivity, specificity and overall
diagnostic accuracy in the detection of myocardial infarction were 100%, 88%,
and 94% for RTPI mode, 88%, 100%, and 94% for HA mode, and 100%, 75%, and 88%
for UH mode. CONCLUSION: All modes of MCE, RTPI, triggered HA mode and triggered
UH mode have excellent diagnostic accuracy in the immediate hour of acute
coronary occlusion within the optimal time frame suitable for reperfusion
therapy.
PMID: 16537001 [PubMed - indexed for MEDLINE]
4: Chin Med J (Engl). 2006 Jan 5;119(1):57-62.
The role of connective tissue growth factor, transforming growth factor beta1
and Smad signaling pathway in cornea wound healing.
Wu XY, Yang YM, Guo H, Chang Y.
Department of Ophthalmology, Qilu Hospital, Shandong University, Ji'nan 250012,
China. xywu8868@ 163.com
PMID: 16454983 [PubMed - indexed for MEDLINE]
5: Chin Med J (Engl). 2006 Jan 5;119(1):37-42.
A new modification of transanal Soave pull-through procedure for Hirschsprung's
disease.
Li AW, Zhang WT, Li FH, Cui XH, Duan XS.
Department of Paediatric Surgery, Qilu Hospital, Shandong University, Ji'nan
250012, China.
liaiwuxie@yahoo.com.cnBACKGROUND: One stage transanal Soave pull-through procedure (TSPP) is a recent
popular operation in the treatment of Hirschsprung's disease (HD). With no
visible scar and a short hospital stay, it is well accepted by surgeons and
mothers. In the conventional Soave procedure, a long rectal muscular cuff left
for anocolic anastomosis might increase the incidence of postoperative
enterocolitis and constipation. This study presents a modified transanal Soave
pull-through procedure (MTSPP) which includes an oblique mucosectomy and an
oblique anastomosis with a short split muscular cuff. METHODS: A review of two
groups of HD patients was made: 112 underwent conventional transanal Soave
procedure from 1999 to 2001 (group 1) and 140 underwent modified transanal Soave
procedure from 2002 to 2004 (group 2). A comparison was made between the two
groups on operative data and postoperative complications. The data included: age
at the operation, operating time, blood loss, time to feeds and hospital stay,
occurrence of postoperative enterocolitis or constipation, need for anal
dilatation, postoperative bowel function and perianal skin problems. RESULTS:
There was no significant difference between two groups with respect to age,
gender, length of colon resected, operating time, blood loss and hospital stay.
However occurrence of postoperative enterocolitis, constipation, anastomotic
stricture and time needed for anal dilatation were evidently less in group 2
(MTSPP). The mean operating time in group 1 was (106 +/- 39) minutes with a
range of 60 to 170 minutes; in group 2 was (101 +/- 36) minutes with a range of
66 to 190 minutes. The average length of the bowel resected in group 1 was (24
+/- 7) cm, range 15 to 58 cm; in group 2 was (26 +/- 8) cm, range 15 to 70 cm.
Two patients, one in each group, required laparoscopic assistance because of
long aganglionic colon. Another patient in group 2 required laparotomy because
of total colonic aganglionosis. Postoperative complications in group 1 included:
temporary perianal excoriation in 34 patients (26 were < 3 months of age),
enterocolitis in 21, anastomotic stricture in 11, recurrent constipation in 12,
cuff abscess in 1, anastomosis leak in 1, soiling in 3 and rectal prolapse in 1.
In group 2 post operative complications included: transient perianal excoriation
in 37 patients (30 were < 3 months of age), enterocolitis in 13, anastomotic
stricture in 5, recurrent constipation in 6, anastomotic leak in 1, adhesive
bowel obstruction in 1 and soiling in 4. Complete bowel continence was found in
97 children (86.6%) in group 1 and in 129 children (92.1%) in group 2 at one
year followup after operation. CONCLUSIONS: Modified transanal Soave
pull-through procedure for HD with oblique mucosectomy and anastomosis and a
short split muscular cuff is a safe and feasible operation with low incidence of
postoperative complication. It is an encouraging improvement of the conventional
transanal Soave pull-through procedure. MTSPP is a preferable choice in the
surgery of HD.
PMID: 16454980 [PubMed - indexed for MEDLINE]
6: Chin Med J (Engl). 2006 Jan 5;119(1):32-6.
Effect of aspirin plus clopidogrel on inflammatory markers in patients with
non-ST-segment elevation acute coronary syndrome.
Chen YG, Xu F, Zhang Y, Ji QS, Sun Y, Lu RJ, Li RJ.
Department of Emergency and Center of Chest Pain, Qilu Hospital of Shandong
University, Ji'nan 250012, China.
BACKGROUND: Aspirin can inhibit inflammatory reactions and platelet aggregation,
but little is known about the effects of the combination of aspirin plus
clopidogrel, a new antiplatelet agent, on inflammation. The purpose of this
study was to determine whether aspirin plus clopidogrel can further suppress
inflammation in patients with non-ST-segment elevation acute coronary syndrome
(NSTEACS). METHODS: One hundred and fifteen patients with NSTEACS were
randomized into two groups: group A (aspirin alone, n =58) and group B (aspirin
plus clopidogrel, n =57). Patients in group A received a loading dose of 300 mg
aspirin, then 100 mg per day. The patients in group B received a loading dose of
300 mg aspirin and 300 mg clopidogrel, then 100 mg aspirin and 75 mg clopidogrel
per day. Serum high sensitivity C-reactive protein (hs-CRP) and tumor necrosis
factor-alpha (TNF-alpha) were measured in all patients at baseline prior to any
drug treatment after admission, and at 7 and 30 days after beginning drug
treatment. Thirty healthy volunteers on no medications were enrolled as controls
(group C). RESULTS: Baseline levels of hs-CRP and TNF-alpha in group A and group
B were significantly higher than those in group C. Seven days after
administration, the levels of hs-CRP in both group A and group B decreased
significantly [Group A: (6.15 +/- 1.39) mg/L vs (9.18 +/- 1.62) mg/L, P <0.01;
Group B:(4.99 +/- 1.62) mg/L vs (10.29 +/- 1.47) mg/L, P <0.01]. Similarly,
levels of TNF- alpha in both groups decreased at 7 days compared to baseline
[Group A: (90.99 +/- 28.91) pg/ml vs (117.20 +/- 37.13) pg/ml, P <0.01; Group B:
(74.32 +/- 21.83) pg/ml vs (115.27 +/- 32.11) pg/ml, P <0.01]. Thirty days after
administration, the levels of hs-CRP in both group A and group B decreased
further to (3.49 +/- 1.53) mg/L, and (2.40 +/- 1.17) mg/L respectively (P <0.01
for both comparisons). Levels of TNF-alpha in groups A and B also decreased
significantly between 7 and 30 days, to 63.28 +/- 29.01 pg/ml (group A) and
(43.95 +/- 17.10) pg/ml (group B; P <0.01 for both comparisons). Significantly
lower levels of hs-CRP and TNF-alpha were observed in group B compared to Group
A at thirty days after initiating drug treatment (P <0.05). CONCLUSIONS: Aspirin
plus clopidogrel treatment reduced levels of serum hs-CRP and TNF-alpha in
patients with NSTEACS significantly more than aspirin alone. Because both
aspirin and clopidogrel produce important anti-inflammatory effects, these
results suggest the possibility that long-term treatment with aspirin plus
clopidogrel may produce greater clinical benefits compared to treatment with
aspirin alone.
Publication Types:
Randomized Controlled Trial
PMID: 16454979 [PubMed - indexed for MEDLINE]
7: Chin Med J (Engl). 2006 Jan 5;119(1):26-31.
Impact of Chinese guidelines for management of patients with acute myocardial
infarction on outcomes of hospitalized patients.
Jiang SL, Ji XP, Zhang C, Wang XR, Zhang M, Zhang Y.
Department of Cardiology, Qilu Hospital of Shandong University, Ji'nan 250012,
China.
BACKGROUND: The first Chinese guidelines for the diagnosis and management of
patients with acute myocardial infarction (AMI) were issued by the
Cardiovascular Branch of the Chinese Medical Association, the Editorial Board of
the Chinese Journal of Cardiology, and the Editorial Board of the Chinese
Circulation Journal in December 2001. However, it is still unclear whether these
guidelines have produced a major impact on clinical practice and patient
outcomes. The purpose of this study was to evaluate the impact of these
guidelines on the management and prognosis of Chinese patients with AMI.
METHODS: A retrospective study was carried out in patients with AMI who were
admitted to Qilu Hospital of Shandong University from January 1994 to December
2004. Patients were divided into two groups: group A included patients admitted
from January 1994 to December 2001, and group B comprised those admitted from
January 2002 to December 2004. Therapeutic approaches and the occurrence rate of
angina pectoris, reinfarction, heart failure and death during hospitalization
were compared between two groups. RESULTS: A total of 1783 patients including
1208 cases in group A and 575 cases in group B were enrolled in this study. No
significant difference was found in baseline characteristics between group A and
group B patients (all P > 0.05). There were more patients undergoing reperfusion
therapy within the first 24 hours after symptom onset in group B than in group A
(35.8% vs 21.7%, P < 0.001). Administration of beta-blockers,
angiotensin-converting-enzyme inhibitors (ACEIs), angiotensin receptor blockers
(ARBs), statins, and heparins were more commonly seen in group B than in group A
(P < 0.001). There were no significant differences in the use of nitrates or
antiplatelet drugs between groups A and B (98.8% vs. 97.9%, P = 0.172, and 97.4%
vs 98.6%, P = 0.113, respectively). In-hospital angina pectoris, heart failure
and death were all lower in group B than in group A (32.2% vs 41.2%, P < 0.001;
17.2% vs 26.2%, P < 0.001; and 6.4% vs 9.4%, P = 0.038, respectively). There was
no significant difference in the rate of reinfarction between group A and B
patients (2.2% vs 1.7%, P = 0.492). CONCLUSIONS: Chinese guidelines for the
management of patients with AMI issued in December 2001 resulted in changes in
therapy that led to a significant improvement of in-hospital outcomes but not in
the rate of reinfarction in patients with AMI.
PMID: 16454978 [PubMed - indexed for MEDLINE]
8: Chin Med J (Engl). 2005 Dec 20;118(24):2041-5.
Endovascular treatment of cerebral arteriovenous malformations with Onyx
embolization.
He HW, Jiang CH, Liu HB, Li YX, Zhang JB, Wu ZX.
Department of Neurosurgery, Qilu Hospital, Shandong University, Jinan 250012,
China.
BACKGROUND: In the past 5 years, new treatment materials and techniques offering
a different concept in endovascular treatment have been described for cerebral
arteriovenous malformations (CAVMs). The aim of this study was to assess the
endovascular treatment of CAVMs by using a liquid embolic material, Onyx (Micro
Therapeutics. Inc., Irvine, CA, USA). METHODS: From September 2003 to September
2004, Onyx was used to treat 22 patients with CAVMs. Ten AVMS were located in
functional areas, 8 in deep cerebral areas, and 4 in the cerebellar hemisphere.
The size of CAVMs was about 3 cm in diameter in 5 patients, 3-6 cm in 11, and
more than 6 cm in 6. RESULTS: In the 22 patients, Onyx embolization was
successful. Nidus occlusion was complete in 3 patients, > 90% in 8, > 80% and <
90% in 6, and > 50% and < 80% in 5. Complications included transient
neurological deficits in 2 patients, and adherence of microcatheter to the site
of injection in 2. CONCLUSIONS: Being non-adhesiveness, Onyx is a safe and
satisfactory embolic material in the treatment of CAVMs. But its long-term
efficacy awaits further follow-up.
PMID: 16438900 [PubMed - indexed for MEDLINE]
9: Chin Med J (Engl). 2005 Nov 20;118(22):1893-9.
The role of NF-kappaB activation in lipopolysaccharide induced keratitis in
rats.
Wu XY, Han SP, Ren MY, Chang Y, Yu FX.
Department of Ophthalmology, Qilu Hospital, Shandong University, Ji'nan 250012,
China.
xywu8868@163.comBACKGROUND: Nuclear factor-kappa B (NF-kappaB) is elevated in regulating
transcription of many cytokines and inflammatory mediators. The purpose of this
study was to investigate the activation and the significance NF-kappaB in
lipopolysaccharide (LPS) induced keratitis. METHODS: LPS induced keratitis model
was based on Wistar rats. At 0.5, 1, 3, 6, 12, 24 or 72 hours after LPS
treatment, the rat corneas were observed with a slit lamp microscope, then the
rats were sacrificed and their corneas were excised for routine histological
analysis. The expression of NF-kappaB was detected with immunohistochemical
staining. The change of tumour necrosis factors-alpha (TNF-alpha) mRNA
expression was identified by reverse transcriptase polymerase chain reaction
(RT-PCR). RESULTS: Histological findings demonstrated that LPS treated corneas
showed significant changes in corneal structure. Corneal edema, pronounced
inflammatory cells infiltration and inordinate collagen fibres were observed.
Immunohistochemical results showed that the expression of NF-kappaB and its
activation obviously increased after LPS treatment compared with the normal
group and control group. Positive cells could be observed at 0.5 hour and peak
expression of NF-kappaB was observed between 3 hours and 12 hours after
infection, but returned to or approached normal level by 72 hours. RT-PCR showed
that the level of TNF-alpha mRNA began to increase 0.5 hour after LPS treatment,
peaked at 6 hours and then subsided by 72 hours. NF-kappaB had a positive
correlation with the expression of TNF-alpha mRNA (r = 0.964, P < 0.01), both
NF-kappaB and TNF-alpha had a strong positive correlation with the degree of
inflammatory response in LPS treated corneas (r = 0.929, P < 0.01; r = 0.587, P
< 0.05, respectively). CONCLUSIONS: The activation of NF-kappaB was increased in
LPS treated corneas and was elevated in LPS induced keratitis by promoting
overexpression of TNF-alpha mRNA. NF-kappaB may play an important role in the
pathogenesis of LPS-associated keratitis in rats.
PMID: 16313844 [PubMed - indexed for MEDLINE]
10: Chin Med J (Engl). 2005 May 20;118(10):854-6.
Relations of nuclear factor-kappa B activity in the kidney of children with
primary nephrotic syndrome to clinical manifestations, pathological types, and
urinary protein excretion.
Zhao HY, Sun RP, Dong JH, Zhen JH.
Department of Pediatrics, Qilu Hospital, Shandong University, Jinan 250012,
China.
liyumei781210@yahoo.com.cnPMID: 15989768 [PubMed - indexed for MEDLINE]
11: Chin Med J (Engl). 2004 Nov;117(11):1687-92.
Function of Delta4 gene and its effects on 32D cell differentiation.
Ji CY, Cui CS, Ma DX, Zhao JQ, Guo NJ, Zhang MH.
Institute of Hematology, Qilu Hospital, Shandong University, Jinan 250012,
China.
jicy@public.jn.sd.cnBACKGROUND: Notch activation leads to transcriptional suppression of
lineage-specific genes, inhibiting differentiation in response to inductive
signals. The Notch signal system contains three parts: Notch molecules, Notch
ligands and effectors. Delta4 is a newly-discovered Notch ligand which has
received the attention of few detailed studies. This study sought to explore the
biological function of Delta4 and observe its effects on 32D cell
differentiation. METHODS: Delta4-expressing vector pTracer.CMV.Delta4.FLAG was
constructed using molecular biological techniques. CHO cells stably transfected
with pTracer.CMV.Delta4.FLAG were confirmed to have a Delta4 protein band via
Western blotting. High-expression Delta4-CHO clones were selected for the
following functional studies. Notch1-CHO and Notch2-CHO were used as host cells.
After transiently transfecting with transition protein 1 (TP1), Delta4 activity
was compared in both cell lines by means of luciferase analysis. CHO cells were
incubated with Notch1-32D cells that had been transfected with Notch1 and were
observed for granulocyte colony-stimulating factor (G-CSF)-induced
differentiation. Jagged2-CHO and Delta4-CHO cells transfected with the Notch
ligands Jagged2 and Delta4, respectively, were incubated with Notch1-32D cells
to observed inhibition of Notch on G-CSF-induced differentiation. RESULTS: The
vector pTracer.CMV.Delta4.FLAG was constructed successfully. CHO cells were
stably transfected with the vector pTracer.CMV.Delta4.FLAG. Two CHO cell lines
expressing Delta4 at high levels were selected for use in the study. Delta4 was
found to induce signal activity via both Notch1 and Notch2 and the induction of
signaling activity was stronger in Notch2 cells than in Notch1 cells. Compared
with other Notch ligands, Delta4 was slightly weaker than Jagged2, but stronger
than Delta1 and Jagged1 in terms of Notch1 ligands. In terms of Notch2, Delta4
had a strong signaling activity, but was weaker than Delta1, Jagged1, and
Jagged2. Jagged2 could inhibit Notch1-32D cell differentiation induced by G-CSF,
but Delta4 could not. CONCLUSIONS: Delta4 induces both Notch1 and Notch2
activity and is a ligand for both of them. The effect of Delta4 is stronger on
Notch2 than that on Notch1. Jagged2 can inhibit Notch1-32D cell differentiation
induced by G-CSF, but Delta4 cannot.
PMID: 15569487 [PubMed - indexed for MEDLINE]
12: Chin Med J (Engl). 2004 Sep;117(9):1293-8.
Establishing an animal model of unstable atherosclerotic plaques.
Chen WQ, Zhang Y, Zhang M, Ji XP, Yin Y, Zhu YF.
Department of Cardiology, Qilu Hospital, Shandong University, Ji'nan 250012,
China.
BACKGROUND: Atherosclerotic plaque rupture and coronary thrombosis are the main
causes of acute coronary syndromes. However, there is no animal model of
unstable atherosclerotic plaques. The presence of the p53 gene in advanced
atherosclerotic plaques and the sensitivity to p53-induced apoptosis of smooth
muscle cells isolated from these plaques prompted us to build an animal model of
unstable atherosclerotic plaques using p53 gene transfer. METHODS: Sixty-four
New Zealand white rabbits were randomly divided into two groups: group A (n=54)
and group B (n=10). Rabbits in group A underwent balloon-induced abdominal
aortic wall injury and were then given a diet of 1% cholesterol, while rabbits
in group B were given a diet of 1% cholesterol without the induction of aortic
wall injury. At the end of the eighth week, rabbits in group A were randomly
divided into two subgroups: group A1 (n=27) and group A2 (n=27). Recombinant
adenovirus carrying p53 or beta-galactosidase (LacZ) genes were injected through
a catheter into the aortic segments rich in plaques in groups A1 and A2,
respectively. Two weeks later, 10 rabbits each from groups A1 and A2 were killed
to observe the occurrence of spontaneous plaque ruptures, and the remaining
rabbits in groups A1, A2, and B all underwent pharmacological triggering with an
injection of Chinese Russell's viper venom (CRVV) and histamine. RESULTS: The
over expression of p53 in group A1 [(32.4 +/- 10.2)% vs (15.8 +/- 3.6)% in group
A2 and (16.2 +/- 6.7)% in group B, P < 0.001, respectively] resulted in a marked
increase in cellular apoptosis [(2.5 +/- 0.8)% vs (1.0 +/- 0.3)% in group A2 and
(0.9 +/- 0.4)% in group B, P < 0.01, respectively], an accumulation of
inflammatory cells within the plaques, and a significant decrease in vascular
smooth muscle cells (VSMCs) and in the thickness of the fibrous caps. Although
spontaneous plaque rupture was rare in group A1, plaque ruptures and thrombosis
occurred in 12 rabbits with a total of 20 lesions after pharmacological
triggering. By contrast, pharmacological triggering led to plaque rupture and
thrombosis in only 5 rabbits for a total of 7 lesions in group A2 and in none of
the rabbits in group B. CONCLUSION: After transfection with human wild-type p53
gene and pharmacological triggering, plaque rupture and thrombosis occur in most
atherosclerotic lesions in rabbits, thus offering a reliable model for the
further study of unstable atherosclerotic plaques.
PMID: 15377416 [PubMed - indexed for MEDLINE]
13: Chin Med J (Engl). 2004 Aug;117(8):1200-3.
Effect of chemical treatment of silicon gel on tissue compatibility.
Wu XY, Yan Y, Du LQ.
Department of Ophthalmology, Qilu Hospital, Shandong University, Jinan 250012,
China.
BACKGROUND: Silicon gel is unfavourable for cell attachment and growth. This
study was to study if pretreating the surface of silicon gel with chemical
agents affects the proliferation of epithelial cells. METHODS: Silicon gel was
made and treated with either mixed acid solution (containing 232 g/dm(3) of
H(2)SO(4) and 8 g/dm(3) of K(2)Cr(2)O(7)) or 300 cm(3)/dm(3) peroxide for 5, 10,
and 15 minutes or 10, 15, and 20 minutes, respectively. The cultured corneal
epithelial cells were seeded onto those silicon gels and kept for 13 days.
Immunohistochemical investigations were then carried out for integrin (alpha 6
or beta 4) and actin. RESULTS: Growth of the epithelial cells in silicon gels
treated with mixed acid solution for 10 minutes and 15 minutes was much
significant than that in the untreated gels. After a 12-hour culture, a small
number of corneal epithelial cells were proliferated on the surface of the
silicon gels that had been treated with peroxide for 15 minutes. After a 3-day
culture, those cells were further proliferated and fused together. The corneal
epithelial cells did not grow well in the silicon gels treated with peroxide for
10 or 20 minutes. Immunostaining revealed the expression of actin and integrin
alpha 6 or beta 4 on the silicon gels that were treated with mixed acid solution
for 10 minutes or peroxide for 15 minutes. CONCLUSION: Silicon gels treated
either with mixed acid solution for 10 or 15 minutes or with peroxide for 15
minutes improves cell proliferation.
PMID: 15361295 [PubMed - indexed for MEDLINE]
14: Chin Med J (Engl). 2004 Aug;117(8):1155-60.
An intervention study to prevent gastric cancer by micro-selenium and large dose
of allitridum.
Li H, Li HQ, Wang Y, Xu HX, Fan WT, Wang ML, Sun PH, Xie XY.
Department of Hematology, Qilu Hospital of Shandong University, Jinan 250012,
China.
BACKGROUND: People have more and more concerned about allitridum as studies have
shown that taking more raw garlic associated with a lower risk for cancers of
the alimentary system. In the present study, we tried to examine whether a large
dose of allitridum and a microdose of selenium prevent gastric cancer. METHODS:
A double-blind intervention study was performed on the participants aged (35 -
74) years, who had matched at least one of the following criteria: (1) a medical
history of stomach disorder, (2) a family history of tumour, or (3) smoking
and/or alcohol consumption. A total of 2,526 and 2,507 persons were randomly
enrolled into intervention group and control group respectively from 288 natural
villages of seven communities in Qixia County, Shandong Province, China. Each
person of the intervention group orally took 200 mg synthetic allitridum every
day and 100 microg selenium every other day for one month of each year during
November 1989 to December 1991. At the same time, people in control group were
given 2 placebo capsules containing corn oid with the identical appearance to
that in the intervention group. RESULTS: For all subjects the large dose of
allitridum was accepted and no harmful side effects were found during the study.
In the first follow-up five years (1992 - 1997) after stopping the intervention,
the morbidity rates of malignant tumours in the intervention group declined by
22%, in contrast to the control group, declined by 47.3%. After adjusting for
age, gender, and other potential confounders, relative risks (RRs) for all
tumours and gastric cancer of the whole population were 0.67 (95% CL: 0.43 -
1.03) and 0.48 (95% CL: 0.21 - 1.06), respectively, and for male group they were
0.51 (95% CL: 0.30 - 0.85) and 0.36 (95% CL: 0.14 - 0.92), respectively. No
signigicantly protective effect was found for the female subgroup. CONCLUSION:
The present study proves that large doses of allitridum and microdorse of
selenium may effectively prevent gastric cancer, especially in men.
Publication Types:
Clinical Trial
Randomized Controlled Trial
PMID: 15361287 [PubMed - indexed for MEDLINE]
15: Chin Med J (Engl). 2004 Mar;117(3):467-70.
Selective percutaneous radiofrequency thermocoagulation in the treatment of
trigeminal neuralgia: report on 1860 cases.
Wu CY, Meng FG, Xu SJ, Liu YG, Wang HW.
Department of Neurosurgery, Qilu Hospital, Shandong University, Ji'nan 250012,
China.
neurosurgeon2000@163.comPMID: 15043796 [PubMed - indexed for MEDLINE]
16: Chin Med J (Engl). 2002 Oct;115(10):1569-72.
Acyclovir for the treatment and prevention of recurrent infectious herpes
simplex keratitis.
Wu X, Chen X.
Department of Ophthalmology, Qilu Hospital, Shandong University, Jinan 250012,
China.
xywu@public.jn.sd.cnOBJECTIVE: To evaluate the role of acyclovir in treatment and prevention of
herpes simplex keratitis (HSK). METHODS: A total of 105 patients with HSK were
divided into 4 groups. Group 1 consisted of 79 patients with HSV epithelial
keratitis. Group 2 consisted of 20 patients with interstitial keratitis. Group 3
consisted of 6 patients with necrotizing keratitis. Group 4 consisted of 4
necrotizing keratitis patients with corneal perforation treated with
conjunctival flap and corneal transplantation. All patients were treated with
acyclovir systemically and topically. After full recovery, the patients with
epithelial HSK and stromal HSK were randomly divided into two groups
individually. One group was constantly treated with oral acyclovir at 300 mg/day
for 1 year as a prophylaxis group. The other group was designated as control.
RESULTS: During the one-year treatment and follow-up, 5 cases with epithelial
HSK recurred in the prophylaxis group and 14 cases in the control group, showing
a statistically significant difference. One case of stromal HSK recurred in the
prophylaxis group and 4 recurred in the control group. CONCLUSION: Long term and
low dose oral acyclovir for prophylaxis of recurrent epithelial herpes simplex
infection and therapeutic doses of oral acyclovir reduce both the rate and
duration of recurrences of infectious herpes simplex keratitis.
Publication Types:
Clinical Trial
Randomized Controlled Trial
PMID: 12490113 [PubMed - indexed for MEDLINE]
17: Chin Med J (Engl). 2002 Sep;115(9):1332-5.
High-intensity focused ultrasound in patients with late-stage pancreatic
carcinoma.
Wang X, Sun J.
Department of Surgery, Qilu Hospital, Shandong University, Jinan 250012, China.
OBJECTIVES: To observe the efficacy of high intensity focused ultrasound (HIFU)
in the treatment of late-stage pancreatic carcinoma and evaluate its influence
on cell-mediated immunity in the host. METHODS: Fifteen patients with late-stage
pancreatic carcinoma had their tumor tissue completely destroyed with HIFU.
Evaluation of efficacy was made on the basis of clinical symptom changes,
variations in tumor echo, changes in pancreatic amylase, serum CA19-9 and CA242,
CD3(+), CD4(+) subsets, CD4(+)/CD8(+) ratios and NK cell activity. RESULTS:
Clinical symptoms such as pain were significantly alleviated, echo of tumor was
enhanced with B-US, CA19-9 and CA242 were decreased and pancreatic amylase
showed no change. Eating, sleeping and mental status were all markedly improved;
no serious complications were seen. On the other hand, NK cell activity was
significantly enhanced in 10 patients (P < 0.05), and CD3(+) and CD4(+) subsets
as well as CD4(+)/CD8(+) ratios increased to different degrees. CONCLUSIONS: The
use of HIFU in the treatment of late-stage pancreatic carcinoma is feasible and
safe. It is effective in destroying the carcinoma and alleviating abdominal
pain; it may enhance cell-mediated immunity in the host. This technique may
offer a noninvasive therapy for the treatment of late-stage pancreatic
carcinoma.
PMID: 12411106 [PubMed - indexed for MEDLINE]
18: Chin Med J (Engl). 2002 Jun;115(6):892-6.
Preservation of laryngeal function in treatment of hypopharyngeal carcinoma.
Wang T, Li X, Lu Y, Yu Z.
Department of Otorhinolaryngology, Qilu Hospital, Shandong University, Jinan
250012, China.
OBJECTIVE: To study the surgical technique and results of laryngeal function
preservation in treatment of hypopharyngeal carcinoma. METHODS: A retrospective
review of 305 patients with malignant neoplasms of the hypopharynx (279 males,
26 females, age ranging from 14 to 77 years) was performed from 1978 to 1996. In
the 305 patients (stage I, n = 6; stage II, n = 12; stage III, n = 82; stage IV,
n = 205), the sites of origin were pyriform sinus (n = 234), postcricoid (n =
21), posterior pharyngeal wall (n = 35) and superior hypopharynx (n = 15). Of
the 305 patients, 206 (67.54%, stage I, n = 6; stage II, n = 12; stage III, n =
65; stage IV, n = 123) were surgically treated with laryngeal function preserved
and 99 (32.46%, stage III, n = 17; stage IV, n = 82) had no laryngeal function
preserved.All had 55-75 Gy radiotherapy according to their need. RESULTS: A
total of 206 patients (67.54%) were surgically treated with laryngeal function
preserved, totally (voice, respiration and deglutition) in 139 (67.5%) and
partially (voice and deglutition) in 67 (32.5%). 99 patients (32.46%) had no
laryngeal function preserved. The overall 5-year survival rate of the 305
patients was 44.8%, which segregated to 83% (stage I), 71% (stage II), 58%
(stage III), and 36% (stage IV). The 5-year survival of the laryngeal function
preserved group was 48% (n = 66), the rate of complications 28% (n = 58) and the
rate of residual tumor 5.8% (n = 12), compared with the no laryngeal function
preserved group 37% (n = 20), 31.3% (n = 31), and 6% (n = 6) (P > 0.05).
CONCLUSION: Only a small proportion of patients (31/305, 10%) with
hypopharyngeal carcinoma who require total laryngectomy and preservation of the
laryngeal function is feasible for eradication of tumor and preservation of
laryngeal function.
PMID: 12123560 [PubMed - indexed for MEDLINE]
