http://www.tijmu.edu.cn/cn/pertea/gongzuodongtai/gzdt4.htm杨熙，男，1954年出生，1982年在山东医科大学获医学学士学位，1985年在上海第二医科大学获核医学硕士学位，1993年在加拿大曼尼托巴大学获免疫学博士学位，现任加拿大曼尼托巴大学医学微生物学、免疫学终身教授。杨熙教授还担任加拿大感染与免疫research主席 (Canada Research Chair in Infection and Immunity)；加拿大曼尼托巴大学免疫学系职称和终身制评定委员会主席（Promotion and Tenure Committee）；加拿大学术顾问委员会委员；加拿大国家医学科研基金评审委员会（免疫组）主席；加拿大卫生研究院免疫与移植委员会评委；曼尼托巴大学医学微生物学系研究生教育委员会主席；中国国家自然科学基金key projects评审委员会委员；Current Medical Chemistry执行编委；Current Pharmaceutical Design执行编委；European Journal of Immunology编委；Infection and Immunity编委；Circulation编委；Clinical and Experimental Immunology编委；Clinical Immunology编委等。杨熙教授主要从事微生物感染免疫学机制及超敏反应细胞和分子机制的研究，在衣原体感染保护性免疫及病理学机制方面的研究工作处于国际领先地位，曾获得多项加拿大政府颁发的科研、学术奖励或荣誉。承担科研项目20余项，共获得资助经费900余万加元。近五年共发表科研论文25篇，其中22篇被SCI收录，13篇代表性论文SCI他引63次，其中1篇被Nature Medicine收录，影响因子达28.588。
http://www.umanitoba.ca/faculties/medicine/units/medical_microbiology/XiYang.htmlDr. Xi Yang
Canada Research Chair In Infection and Immunity
Professor, Department of Medical Microbiology
Professor, Department of Immunology
Chairman, Graduate Studies Committee
Department of Medical Microbiology, University of Manitoba
Degrees:
M.D. (Shandong, 1982), M.Sc. (Shanghai, 1985), Ph.D. (Manitoba, 1993)
Mailing Address:
Department of Medical Microbiology
730 William Avenue, Room 523
Winnipeg, MB R3E 0W3
Tel: (204) 789-3481 Fax: (204) 789-3926 Lab: (204)789-3298
E-mail:
yangxi@cc.umanitoba.ca Research Interests:
The current research program in my laboratory focuses on the cellular and molecular basis of immune responses to allergens and infectious agents and on development of immunoprophylactic approaches for allergy and infectious diseases.
Project I. Study of the molecular basis of the causal relationship between the decline of infection and the increase of atopic allergy in developed countries. The objective of the study is to elucidate the mechanism underlying the long-term documented but unexplained mystery that as many countries reduce the burden of infectious diseases, a remarkable increase in the incidence of atopic allergies has occurred. Specifically, the project is to study (I) mechanisms by which intracellular bacterial infection inhibits de novo and established allergic responses; (ii) genetic factors influencing the manipulating effect of intracellular bacterial infections on allergic responses; and (iii) development of a engineered vaccine to universally inhibit atopic allergy.
Project II. Study of the protective immunity and immunopathology to chlamydial infection. The objective of the study is to dissect the cellular and molecular basis for chlamydial protective immunity and pathology with an emphasis on the immunopathological reactions including cardiovascular pathology. Specifically, this project will analyze: (I) the role of dendritic cells, cytokines (chemokines) and adhesion molecules in the development or prevention of immunopathological responses; (ii) the genetic basis for susceptibility to chlamydial infection by mapping and cloning the gene(s) controlling susceptibility to chlamydial infection; and (iii) the mechanism by which chlamydia infection induces cardiovascular diseases.
Project III. Development of DNA vaccine for human chlamydial infection. The objective of the project is to develop a human vaccine against chlamydial infection using DNA vaccination approach. The first is to transfect BCG using DNA plasmids containing different chlamydial genes including MOMP genes. By using different plasmids, the chlamydial proteins can be expressed in the cytoplasm or surface of BCG or being secreted. The advantage for using BCG as a vector is that BCG is a strong adjuvant for Th1 type immune responses and it has been shown that protective immunity to chlamydial infection is Th1 type responses. The second approaches is to add genes encoding cytokines, chemokines or dendritic cell targeting molecules in the DNA plasmid containing chlamydial genes to enhance the Th1 type immune responses, the recruitment immune cells and antigen presentation.
Project IV. Development of new method in diagnostics and treatment of cardiac ischemia and infarction. This is a group grant granted by CIHR/NRC at an amount of over one million dollars for three years (2004-2007) to myself (PI) and a group of scientists in Institute for Biodiagnostics , NRC. This study involves the utilization of new MRI method (utilization of contrast agent and special pulses) to diagnose cardiac infarction in vivo using a pig model and comparison of the MRI method with optical imaging (measures light reflected from the heart surface and detects changes in blood oxygenation). These method will also be applied for evaluation of the efficiency of bone marrow stem cells in regeneration of the infarct area. The cells will be loaded with “report” genes that produce fluorescent or/and luminescent products, which will permit observation of cell fate and their distribution using optical imaging.
Recent Publications:
S. Wang, Y. Fan, and X. Han, J. Yang, L. Bilenki, X. Yang. IL-12 dependent VCAM-1 expression contributes to airway eosinophilic inflammation in a mouse model of asthma -like reaction. J. Immunol. 166:2741-2749, 2001.
X. Yang. Does allergen immunotherapy alter the natural course of allergic disorders? (Invited review). Drugs, 61:365-374, 2001.
X. Yang. Distinct functions of Th1 and Th2 type responses in delayed type hypersensitivity: Defence against chlamydial infection (invited review). Microscopy Research and techniques, 53:273-277. 2001.
X. Yang, S. Wang, Y. Fan, X. Han, J. Yang and L. Chen. Mycobacterial infection inhibits established allergy responses by modifying cytokine production and adhesion molecule expression. Immunology 105:336-343, 2002
L. Bilenki, Y. Fan, S. Wang, J. Yang, X. Han, X. Yang. Chlamydia trachomatis infection inhibit asthma-like reaction induced by ragweed. Clin. Immunol.102:28-36, 2002
X. Yang. Cytokine responses in chlamydial diseases (invited review). Curr Pharm Design, 9:67-73, 2003.
X. Han, Y. Fan, S. Wang, J. Yang, X. Yang. Role of dendritic cells in infection mediated inhibition of airway inflammation. Eur J Immunol. In press.
X. Han, Y. Fan, S. Wang, J. Yang, X. Yang. Role of dendritic cells in infection mediated inhibition of airway inflammation. Eur J Immunol, 34:981-989, 2004
L. Bilenki, Y. Fan, J. Yang, S. Wang and X. Yang. Natural killer T (NKT) cells contribute to airway eosinophilic inflammation induced by ragweed through enhanced IL-4 and eotaxin production. Eur J Immunol, 34:345-354, 2004
H. Qiu, J. Yang, H. Bai, Y. Fan, S. Wang, Xiaobing Han, L. Chen and X. Yang. Less inhibition of interferon-r to organism growth in host cells may contribute to the high susceptibility of C3H mice to Chlamydia trachomatis lung infection. Immunology, 111:453-461, 2004
H. Bai, J. Yang, H. Hiu, S. Wang, Y. Fan, X. Han, S. Xie and X. Yang. Intranasal inoculation of Chlamydia trachomatis mouse pneumonitis agent (MoPn) induces significant neutrophil infiltration which is not efficient in controlling the infection in mice. Immunology, Feb 2005.
L. Bilenki, S. Wang, J. Yang. Y. Fan, J. Gorge and X. Yang. Natural Killer T (NKT) Cell Activation promotes Chlamydia trachomatis Infection in vivo J. Immunol. in press, 2005.
