[杏林风采]关于Wenjun Guo的一点疑问 [复制链接]

INTEGRIN SIGNALLING DURING
TUMOUR PROGRESSION
Wenjun Guo and Filippo G. Giancotti
Abstract | During progression from tumour growth to metastasis, specific integrin signals enable
cancer cells to detach from neighbouring cells, re-orientate their polarity during migration, and
survive and proliferate in foreign microenvironments. There is increasing evidence that certain
integrins associate with receptor tyrosine kinases (RTKs) to activate signalling pathways that are
necessary for tumour invasion and metastasis. The effect of these integrins might be especially
important in cancer cells that have activating mutations, or amplifications, of the genes that
encode these RTKs.

郭文军Cell文章：肿瘤信号途径新发现

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[作者:生物通记者 杨遥]
[发布时间:20060815]
[来源:http://www.ebiotrade.com/newsf/read.asp?page=200681592126 中国科学技术信息研究所加工整理]




  生物通2006年8月15日报道   来自纪念Sloan-Kettering癌症研究中心的华人科学家郭文军（Wenjun Guo）以及康奈尔大学等研究机构的同事发现β4整合素能够放大ErbB2信号途径，从而促进乳腺肿瘤的发生。研究的结果刊登在8月10日的Cell杂志上。

  ErbB2基因编码一种受体酪氨酸激酶，ErbB2在恶性乳腺肿瘤中通常都发生了扩增，并且与差的预后有关。到目前为止，ErbB2介导的乳腺肿瘤发展机制还没有被完全确定出来。

  为了分析这个信号途径和细胞附着受体（cell-adhesion receptor）整合素β4在ErbB2介导的肿瘤发生过程中的作用，这个研究组将ErbB2诱导的乳腺肿瘤小鼠模型定向删除了β4信号结构域。结果发现，丧失了β4信号途径能抑制乳腺肿瘤的发生和侵入生长。另外的实验证实β4能与ErbB2形成一个复合体并促进转录因子STAT3和c-Jun的活化。STAT3能促进上皮粘附状性和极性的破坏，而c-Jun则是过度增殖所必须的因子。

  最终，β4信号区域的删除提高了ErbB2靶向治疗的效果。这些结果表明β4整合素能够通过放大ErbB2信号途径来促进肿瘤的进级，并且还确定出β4是乳腺癌分子治疗的一个很有潜力的靶标。

这两个文章中的guo 是一个人吗?
谢谢

是一个人的。这个研究所非常牛的。不过作者的网页上面现在找不到他，估计离开这个实验室了。

http://www.mskcc.org/mskcc/html/10756.cfm

Author biographies

Wenjun Guo received a B.Sc. from Nankai University and an M.Sc. from Fudan University in China. He is currently pursuing his Ph.D. under the guidance of Filippo Giancotti in the Sloan-Kettering Division of Weill Graduate School of Medical Sciences of Cornell University, USA. He is studying the role of integrin alpha6beta4 signalling in mammary tumorigenesis by molecular-genetics methods.

Filippo G. Giancotti received his M.D. and Ph.D. degrees from the University of Torino, Italy, and his Board Certification in Hematology and Oncology from the University of Rome, Italy. He received postdoctoral training at the Burnham Institute in La Jolla, California, USA, with Erkki Ruoslahti, and then joined the Department of Pathology of New York University School of Medicine as an assistant professor. Since 1996, he has headed the Laboratory of Cell Adhesion and Signaling at the Sloan-Kettering Institute for Cancer Research of Memorial Sloan-Kettering Cancer Center in New York, USA. Since 2000, he has been a member of the Cell Biology Program of Sloan-Kettering Institute and a professor of Cell Biology and Genetics in the Sloan-Kettering Division of Weill Graduate School of Medical Sciences of Cornell University. The Giancotti laboratory studies the mechanisms by which integrins and other adhesion receptors control cell fate and the contributions of adhesion signalling to development and cancer.

这个Filippo Giancotti发10分以上的杂志基本相当于山医老师发《山东医药》的难度了。呵呵
1: Okada T, You L, Giancotti FG.
Shedding light on Merlin's wizardry.
Trends Cell Biol. 2007 May;17(5):222-9. Epub 2007 Apr 17.
PMID: 17442573 [PubMed - in process]

2: Guo W, Pylayeva Y, Pepe A, Yoshioka T, Muller WJ, Inghirami G, Giancotti FG.
Beta 4 integrin amplifies ErbB2 signaling to promote mammary tumorigenesis.
Cell. 2006 Aug 11;126(3):489-502.
PMID: 16901783 [PubMed - indexed for MEDLINE]

3: Pylayeva Y, Giancotti FG.
Development requires activation but not phosphorylation of beta1 integrins.
Genes Dev. 2006 May 1;20(9):1057-60. No abstract available.
PMID: 16651652 [PubMed - indexed for MEDLINE]

4: Okada T, Lopez-Lago M, Giancotti FG.
Merlin/NF-2 mediates contact inhibition of growth by suppressing recruitment of
Rac to the plasma membrane.
J Cell Biol. 2005 Oct 24;171(2):361-71.
PMID: 16247032 [PubMed - indexed for MEDLINE]

5: Nikolopoulos SN, Blaikie P, Yoshioka T, Guo W, Puri C, Tacchetti C, Giancotti
FG.
Targeted deletion of the integrin beta4 signaling domain suppresses
laminin-5-dependent nuclear entry of mitogen-activated protein kinases and
NF-kappaB, causing defects in epidermal growth and migration.
Mol Cell Biol. 2005 Jul;25(14):6090-102. Erratum in: Mol Cell Biol. 2005
Sep;25(17):7926.
PMID: 15988021 [PubMed - indexed for MEDLINE]

6: Nikolopoulos SN, Giancotti FG.
Netrin-integrin signaling in epithelial morphogenesis, axon guidance and vascular
patterning.
Cell Cycle. 2005 Mar;4(3):e131-5. Epub 2005 Mar 18. Review.
PMID: 15725728 [PubMed - indexed for MEDLINE]

7: Nikolopoulos SN, Blaikie P, Yoshioka T, Guo W, Giancotti FG.
Integrin beta4 signaling promotes tumor angiogenesis.
Cancer Cell. 2004 Nov;6(5):471-83.
PMID: 15542431 [PubMed - indexed for MEDLINE]

8: Guo W, Giancotti FG.
Integrin signalling during tumour progression.
Nat Rev Mol Cell Biol. 2004 Oct;5(10):816-26. Review.
PMID: 15459662 [PubMed - indexed for MEDLINE]

9: Giancotti FG, Tarone G.
Positional control of cell fate through joint integrin/receptor protein kinase
signaling.
Annu Rev Cell Dev Biol. 2003;19:173-206. Review.
PMID: 14570568 [PubMed - indexed for MEDLINE]

10: Gagnoux-Palacios L, Dans M, van't Hof W, Mariotti A, Pepe A, Meneguzzi G,
Resh MD, Giancotti FG.
Compartmentalization of integrin alpha6beta4 signaling in lipid rafts.
J Cell Biol. 2003 Sep 29;162(7):1189-96.
PMID: 14517202 [PubMed - indexed for MEDLINE]

11: Giancotti FG.
A structural view of integrin activation and signaling.
Dev Cell. 2003 Feb;4(2):149-51. Review.
PMID: 12586058 [PubMed - indexed for MEDLINE]

12: Klein S, de Fougerolles AR, Blaikie P, Khan L, Pepe A, Green CD, Koteliansky
V, Giancotti FG.
Alpha 5 beta 1 integrin activates an NF-kappa B-dependent program of gene
expression important for angiogenesis and inflammation.
Mol Cell Biol. 2002 Aug;22(16):5912-22.
PMID: 12138201 [PubMed - indexed for MEDLINE]

13: Hirsch E, Barberis L, Brancaccio M, Azzolino O, Xu D, Kyriakis JM, Silengo L,
Giancotti FG, Tarone G, Fassler R, Altruda F.
Defective Rac-mediated proliferation and survival after targeted mutation of the
beta1 integrin cytodomain.
J Cell Biol. 2002 Apr 29;157(3):481-92. Epub 2002 Apr 29.
PMID: 11980921 [PubMed - indexed for MEDLINE]

14: Mariotti A, Kedeshian PA, Dans M, Curatola AM, Gagnoux-Palacios L, Giancotti
FG.
EGF-R signaling through Fyn kinase disrupts the function of integrin alpha6beta4
at hemidesmosomes: role in epithelial cell migration and carcinoma invasion.
J Cell Biol. 2001 Oct 29;155(3):447-58. Epub 2001 Oct 29.
PMID: 11684709 [PubMed - indexed for MEDLINE]

15: Dellambra E, Prislei S, Salvati AL, Madeddu ML, Golisano O, Siviero E,
Bondanza S, Cicuzza S, Orecchia A, Giancotti FG, Zambruno G, De Luca M.
Gene correction of integrin beta4-dependent pyloric atresia-junctional
epidermolysis bullosa keratinocytes establishes a role for beta4 tyrosines 1422
and 1440 in hemidesmosome assembly.
J Biol Chem. 2001 Nov 2;276(44):41336-42. Epub 2001 Aug 24.
PMID: 11522777 [PubMed - indexed for MEDLINE]

16: Mettouchi A, Klein S, Guo W, Lopez-Lago M, Lemichez E, Westwick JK, Giancotti
FG.
Integrin-specific activation of Rac controls progression through the G(1) phase
of the cell cycle.
Mol Cell. 2001 Jul;8(1):115-27.
PMID: 11511365 [PubMed - indexed for MEDLINE]

17: Dans M, Giancotti FG.
CD104.
J Biol Regul Homeost Agents. 2001 Apr-Jun;15(2):193-6. No abstract available.
PMID: 11501983 [PubMed - indexed for MEDLINE]

18: Sumitomo M, Shen R, Walburg M, Dai J, Geng Y, Navarro D, Boileau G,
Papandreou CN, Giancotti FG, Knudsen B, Nanus DM.
Neutral endopeptidase inhibits prostate cancer cell migration by blocking focal
adhesion kinase signaling.
J Clin Invest. 2000 Dec;106(11):1399-407.
PMID: 11104793 [PubMed - indexed for MEDLINE]

19: Dans M, Gagnoux-Palacios L, Blaikie P, Klein S, Mariotti A, Giancotti FG.
Tyrosine phosphorylation of the beta 4 integrin cytoplasmic domain mediates Shc
signaling to extracellular signal-regulated kinase and antagonizes formation of
hemidesmosomes.
J Biol Chem. 2001 Jan 12;276(2):1494-502.
PMID: 11044453 [PubMed - indexed for MEDLINE]

20: Barberis L, Wary KK, Fiucci G, Liu F, Hirsch E, Brancaccio M, Altruda F,
Tarone G, Giancotti FG.
Distinct roles of the adaptor protein Shc and focal adhesion kinase in integrin
signaling to ERK.
J Biol Chem. 2000 Nov 24;275(47):36532-40.
PMID: 10976102 [PubMed - indexed for MEDLINE]

这个Filippo Giancotti发10分以上的杂志基本相当于山医老师发《山东医药》的难度了.......

呵呵
这么好
据说山东医药
比较容易发

中国医学杂志里面周刊不多，中华医学杂志与山东医药就是少数之一。

引用第5楼merck于2007-06-13 16:22发表的:中国医学杂志里面周刊不多，中华医学杂志与山东医药就是少数之一。

虽然都是周刊，但周刊与周刊差距实在太大了，就上述两个差距也够大的

引用第6楼yjmforever于2007-06-26 13:58发表的:虽然都是周刊，但周刊与周刊差距实在太大了，就上述两个差距也够大的

PNAS, JBC, JACS, NATURE等也是周刊，前面的3本很厚。

引用第5楼merck于2007-06-13 16:22发表的:中国医学杂志里面周刊不多，中华医学杂志与山东医药就是少数之一。

山东医药现在仍然是月刊
周刊没批

本刊为旬刊，每期72页码，每期定价6元，可破季订阅。
http://www.sdwsbks.com.cn/file/5.htm