: Int J Immunogenet. 2006 Aug;33(4):303-6.
Lack of association between ADAM33 gene and asthma in a Chinese population.
Wang P, Liu QJ, Li JS, Li HC, Wei CH, Guo CH, Gong YQ.
Institute of Medical Genetics, School of Medicine, Shandong University, Jinan,
China.
Asthma is a complex polygenic disease with gene-environment interactions being
important. It has been previously suggested that ADAM33, which is a member of a
gene family that encodes membrane-anchored proteins with a disintegrin and a
metalloprotease domain, is primarily expressed in lung fibroblasts and bronchial
smooth muscle cells and has been associated with airway remodelling and
bronchial hyperresponsiveness. A significant association has previously been
demonstrated between single nucleotide polymorphisms (SNPs) and haplotypes of
the ADAM33 and asthma in ethnically diverse populations. To assess whether SNPs
or haplotypes of ADAM33 are related to asthma in a Chinese Han population, we
genotyped three SNPs of ADAM33 (7575G/A in intron 6, 11188A/T in intron 19, and
12433T/C in exon 20) in a case-control study involving 296 patients with asthma
and 270 healthy controls. No significant association was detected between these
three SNPs and asthma susceptibility in the Chinese population.
PMID: 16893396 [PubMed - in process]
这个文章的第一作者可能是俺的熟人喔
