引用第8楼jon于2007-08-11 04:10发表的:只是奇怪，ubc没毕业的phd也可以当泰山学者？按这种标准，岂不太松了？
http://www.neuroscience.ubc.ca/sun.htm Xiulian Sun
* 1999, Bachelor of Medicine, Medical College of Nankai University
* 2001, Master of Medicine, Medical College of Nankai University
Department: Dept. of Psychiatry
email:
xiulians@interchange.ubc.caLab Phone: 604-822-7383
Fax: 604-822-7981
Research Description:
I am currently interested in the molecular pathogenesis of Alzheimer's disease. AD is the most common cause of dementia in the elderly population. The mechanism of neurodegeneration remains unknown. However, familial AD mutations strongly support the "amyloid hypothesis", in which beta-secretase plays an important role in beta-amyloid deposition in AD brains. By using the transgenic models of AD, I am looking into the genetic factors and environmental factors that may regulate the beta-secretase activity.
Selected References:
Sun X, Tong Y, Qing H, Chen A, and Song W (2006) Increased BACE1 Maturation contributes to Alzheimer's Disease pathogenesis in Down Syndrome. The FASEB Journal 20(9):1361-8.
Sun X, He G and Song W. (2006) BACE2, as a novel APP q-secretase, is not responsible for the pathogenesis of Alzheimer's Disease in Down Syndrome. The FASEB Journal 20(9):1369-76.
Sun X, Wang Y, Qing H, Christensen MA, Liu Y, Zhou W, Tong Y, Xiao C, Huang Y, Zhang S, Liu X, and Song W. (2005) Distinct Transcriptional Regulation and Function of The Human BACE2 and BACE1 Genes. The FASEB Journal 19(7):739-749.
Qing H, Zhou W, Christensen MA, Sun X, Tong Y, and Song W. (2004) egradation of BACE by the Ubiquitin-Proteasome Pathway. The FASEB Journal 18(13):1571-3.
Tong Y, Zhou W, Fung V, Christensen MA, Qing H, Sun X, and Song W (2005).Oxidative stress potentiates BACE1 gene expression and Ab Generation. Journal of Neural Transmission 112(3):455-69.
Published Abstracts:
Sun, X., Tong, Y., Qing, H., Chen, C-H., and Song, W. (2006). Increased BACE1 maturation in Down Syndrome. Alzheimer's & Dementia 2, S532, P4-064.
Song, W., Sun, X., Zhou, W., Qing, H., He, G., and Staufenbiel, M. (2006). Hypoxia facilitates Alzheimer's disease pathogenesis. Alzheimer's and Dementia 2, S545, P4-104.
Song, W., Sun, X., and He, G. (2006). BACE2 as a novel q-secretase and its role in DS. Alzheimer's and Dementia ICAD Hot Topic, P4-477.
Sun X., Zhou W., and Song W. (2004). Transcriptional regulation of DSCR1 gene. Neurobiology of Aging. 25, S173.
Qing H., Zhou W., Christenten M., Sun X., Tong Y., and Song W. (2004). Degradation of BACE by the Ubiquitin-Proteasome Pathway. Neurobiology of Aging. 25, S528.
Tong Y., Zhou Y., Fung Y., Christensen M. A., Qing H., Sun, X., and Song W.(2004). Oxidative Stress Potentiates BACE1 Gene Expression and Ab Generation. Neurobiology of Aging. 25, S531.
Poster presentations
Sun X, Wang Y, Qing H, Liu Y, Zhou W, and Song W. (2005) Functional analysis of the human BACE2 gene promoter and the role of BACE2 proteins in APP processing. Soc. Neurosci. Abstr. 661.14
Song W, Sun X, Tong Y, Qing H, and Chen A. (2005) BACE1 but not BACE2 contributes to the Alzheimer's disease pathogenesis in Down Syndrome. Soc. Neurosci. Abstr. 1004.7
Sun X., Zhou W., Qing H., Tong Y., and Song W. (2004). DSCR1 mediates the neuronal loss in Down Syndrome and Alzheimer Disease. Soc. Neurosci. Abstr. 92.8.
Tong Y., Zhou Y., Fung Y., Christensen M. A., Qing H., Sun, X., and Song W. Oxidative Stress Potentiates BACE1 Gene Expression and Ab Generation. Soc. Neurosci. Abstr. 441.4
Sun X., Zhou W., and Song W. (2003). Molecular cloning and characterization of the human DSCR1 gene promoter. Soc. Neurosci. Abstr. 646.18.
Qing H., Zhou W., Christenten M., Tong Y., Sun X., and Song W. (2003). Ubiquitin-Proteasome Pathway Mediates the Degradation of b-Secretase. Soc Neurosci. Abstr. 773.1.
http://www.cihr-irsc.gc.ca/e/30779.htmlJune 2005 Age Plus Prize Winner
Xiulian SunXiulian Sun, University of British Columbia
Distinct transcriptional regulation and function of the human BACE2 and BACE1 genes
Memory is precious for the elderly, their family and society. Alzheimer's disease is a devastating disease affecting the memory of the elderly. At the moment, there is no cure for this disease. Ms. Sun's paper addresses the molecular pathogenesis of Alzheimer's disease to help to find the cure for the disease.
Her research studied some of the genes involved in the pathogenesis of Alzheimer's disease. BACE1 and BACE2 are two active proteins (i.e., enzymes) involved in the progression of Alzheimer's disease; she studied the mechanism of how the BACE1 and BACE2 genes were regulated and their roles in disease progress.
Elucidation of the cause of disease at the molecular level is important in drug development in order to treat disease. Her research found that the BACE2 enzyme can potentially reduce the pathological abnormalities of Alzheimer's disease. Manipulations that can increase or mimic BACE2 function were explored to treat Alzheimer's disease.
To improve health care is Ms. Sun's career goal. Although she received some knowledge about diseases from her previous training in medical school, research is vital to better health care. This research project allowed her to learn how to do research and how to make research useful in developing treatments.
Ms. Sun is currently on her way to obtaining a Ph.D. degree in neuroscience. After getting her degree, she intends to engage in postdoctoral research for a few years, which will help her polish her research techniques in order to become an independent researcher in the future.
http://www.neuroscience.ubc.ca/song_personnel.htm[ 此贴被merck在2007-08-11 09:32重新编辑 ]
