2006医学海外校友代表团系列活动之科学畅想曲|:: 基础课程 :: - 啄木论坛

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只看楼主倒序阅读使用道具 0楼发表于: 2006-04-19

科学畅想曲（两场）
1．报告人：于学杰（医学院）
题目：“Emerging Infectious Diseases and Biodefense”
2．报告人：王山鸣（生命科学学院）
题目：“Decoding Everyone’s Genome”

周四 13：30-15：30
综合楼三层报告厅

另有小树林文化论坛一场，信息如下：
http://www.msw.sdu.edu.cn/bbs/read.php?tid=9231

于学杰，医学博士，理学硕士、博士，德克萨斯大学盖尔文斯顿医学院病理系和微生物及免疫系终身副教授，生物防御及新生传染疾病中心科学家，Sealy疫苗开发中心科学家。于博士于1983年毕业于山东医科大学，1988年获中国预防医学科学院预防医学硕士学位，1993年获法国马赛地中海大学分子微生物学博士学位。1983年至1992年工作于中国预防医学科学院流行病学及微生物学研究所,并于1989年提升为助理研究员。其间他作为访问科学家在美国工作过两年，后于1988年返回中国。1992至1993年他在法国地中海大学工作并获得博士学位。1993年起在美国的德克萨斯大学医学院做博士后、讲师，1997年升为助理教授，2003年获终身副教授职位。于博士获得多项研究资助,其中包括美国国立健康研究院过敏及传染性疾病学会的R01和U01资助, 获得多项美国专利。他在欧美英文杂志上发表了五十多篇文章，参与写作了最具权威的医学微生物学参考书, 其中包括医学微生物学、预防生物恐怖袭击与新生传染疾病疫苗、真核生物和伯杰（Bergey）细菌系统分类手册。于博士对传染性疾病和生物防御有广泛的兴趣。作为研究虫媒传播细胞内寄生菌（如Rickettsia, Ehrlichia）的主要科学家之一，他的研究兴趣在于阐明虫媒传播细胞内寄生菌的分子发病机理及如何防御新生传染病和生物恐怖袭击。于博士多次担任美国国立健康研究院及其他基金评审专家。他对医学微生物及生物防御的研究曾引起休斯敦中文报纸美南新闻的关注、报道。于博士积极参与、支持当地中国人社区活动，曾任德克萨斯大学盖尔文斯顿医学院中国学者学生会副主席。于博士和夫人张立红创立了德克萨斯州盖尔文斯顿市中文学校。

王山鸣博士, 1986年毕业于山东医科大学微生物系，获硕士学位。毕业后在中国中医研究院工作。1989年赴瑞士实验癌症研究所学习，于1994年获博士学位。同年到美国西北大学进行博士后研究，后转入芝加哥大学继续博士后研究并留校任教。2004年，回西北大学任助理教授并出任ENH研究所功能基因组中心主任。主要兴趣有：了解人类基因组的基本结构，探索人类基因组在生理和病理条件下的动态转化模式。主要贡献有：发展和改进了数项用于大规模分析基因组结构及基因表达的高通量技术，揭示了在人类基因组及果蝇基因组中存有大量新基因，确定了人类造血系统细胞分化的正常基因表达谱，分析了急性粒细胞白血病基因组的异常基因表达特征。王山鸣博士的研究得到美国国立卫生研究院的资助。他目前的研究方向包括：鉴定人类新基因, 探索人类正常基因组变异性, 分析癌症基因组的结构改变, 以用于癌症的诊断和治疗。

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离线merck

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只看该作者 1楼发表于: 2006-04-20

http://www.enh.org/researchandacademics/research/investigators/principal/default.aspx?id=2272
Wang, MD, San Ming

San Ming Wang, MD
Director, Center for Functional Genomics

Director, Center for Functional Genomics

Undergraduate: Bachelors of Medicine, Jiangxi Medical College, Jiangxi, China
Masters of Medicine-Immunology, Shandong Medical University, Shandong, China
Medical School: M.D., Swiss Institute for Experimental Cancer Research, Lausanne, Switzerland
Post-Doctoral Fellowship : Gene Expression, Northwestern University and University of Chicago

Northwestern University's Feinberg School of Medicine Rank: Assistant Professor of Medicine, Division of Genetics

Research Interests:
Use whole genome approaches to study genetic bases for normal hematopoiesis and genetic disorders related to leukemogenesis.

Book Editor:
SAGE Techologies: Current Innovations and Future Trends. Horizon Scientific Press, London. Editor: SM Wang(2005).

Selected References:

1.
P Sperisen, SM Wang, P Bucher, P Corthesy, P Reichbach, M Nabholz. The Biphasic Transcriptional Response of the IL2R Gene to IL1 and IL2 reflects bipartotie structure of the 5' flanking region. Journal of Biological Chemistry 270(18) :10743-10753, 1995.
2.
SM Wang, J Khandekar, K Kaul, D Winchester, R Morimoto. A method for the quantitative analysis of human heat shock gene expression using a multiplex RT-PCR assay. Cell Stress and Chaperones 4(2) : 77-82, 1999
3.
SM Wang, JD Rowley. A Strategy for Gene Identification: Integrated Procedure for Gene Identification. Proc. Natl. Acad. Sci. USA 95 :11909-11914, 1998.
4.
SM Wang, SC Fears, L Zhang, J-J Chen, JD Rowley. Screening poly dA/dT(-) cDNAs for gene identification. Proc. Natl. Acad. Sci. USA 97 :4162-4167, 2000. COMMENTARY by K.J., Martin and A.B., Pardee. Identifying expressed genes Proc. Natl. Acad. Sci. USA 97:3789-3791, 2000.
5.
G Zhou, J Chen, S Lee, T Clark, JD Rowley, SM Wang. The pattern of gene expression in human CD34+ hematopoietic stem/progenitor cells. Proc. Natl. Acad. Sci. USA 98 :13966-13971, 2001.
6.
S Lee, G Zhou, T Clark, J Chen, JD Rowley, SM Wang. The pattern of gene expression in human CD15+ myeloid progenitor cells. Proc. Natl. Acad. Sci. USA 98 :3340-3345, 2001.
7.
J Chen, D Rowley, T Clark, S Lee, G Zhou, C Cheers, JD Rowley, SM Wang. Genome-level identification of expressed genes in mouse Gr-1+ myeloid progenitor cells. Genomics 77 :149-162, 2001.

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离线merck

啄木顾问

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只看该作者 2楼发表于: 2006-04-20

http://microbiology.utmb.edu/faculty/xue/xue.htm
Xue-Jie Yu, M.D., Ph.D.

PRESENT POSITION:
Assistant Professor
Department of Pathology, WHO Collaborative Center for Tropical Diseases, and Microbiology and Immunology
University of Texas Medical Branch
301 University Boulevard
Galveston, Texas 77555-0609
(409) 772-4813 (Laboratory) (409) 747-1786 (Office)
(409) 747-2415 (Fax ) Email: xuyu@utmb.edu

EDUCATION:
1993 Ph.D., Cellular Biology and Microbiology, Universite D'Aix-Marceille II, Marseille, France

1988 Masters, Preventive Medicine, Chinese Academy for Preventive Medicine, Beijing, P. R. China

1983 M.D., Shandong Medical University, Jinan, Shandong, P. R. China

PROFESSIONAL:
2001 - Current Assistant Professor, Department of Pathology, WHO Collaborative Center for Tropical Diseases, and Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas

1997 - 2001 Assistant Professor, Department of Pathology, University of Texas Medical Branch, Galveston, Texas

1996 – 1997 Instructor, Department of Pathology, University of Texas Medical Branch, Galveston, Texas

1993 – 1996 Post-doctoral Fellow, Department of Pathology, University of Texas Medical Branch, Galveston, Texas

1992 – 1993 Doctorate, Unite des Rickettsies, Faculte de Medecine , Marseille, France

1989 – 1992 Assistant Professor, Rickettsial Laboratory, Institute of Epidemiology and Microbiology, Chinese Academy for Preventive Medicine, Beijing, China

1987 – 1988 Visiting Scientist, Department of Pathology, University of Texas Medical Branch, Galveston, Texas

1987 Visiting Scientist, Department of Pathology, University of North Carolina, Chapel Hill, North Carolina

1983 – 1987 Instructor, Institute of Epidemiology and Microbiology, Chinese Academy for Preventive Medicine, Beijing, China

Ad Hoc reviewer:

* Veterinary Microbiology
* American Journal of Tropical Medicine and Hygiene

RESEARCH ACTIVITIES:

12/01/01 – 11/30/04 1 R01 A145871-01A2, Principal Investigator, National Institutes of Allergy and Infectious Diseases, “Molecular basis of persistent Ehrlichia infection”

09/01/00 – 08/31/02 1U01AI49040-01, Co-investigator (Principle investigator: Walker, D.H.), National Institutes of Allergy and Infectious Diseases, Complete Genome Sequence of Rickettsia typhi

MEMBERSHIP IN SCIENTIFIC SOCIETIES:

* American Society for Microbiology
* American Society of Tropical Medicine and Hygiene
* American Association for the Advancement of Science
* American Society of Rickettsiology

PATENTS:

"Immunodominant 120-kDa surface-exposed adhesion protein genes of Ehrlichia chaffeensis"; Inventors: David H. Walker, M.D., and Xue-Jie Yu, M.D., Ph.D.

“Homologous 28-kilodaton immunodominant protein genes of Ehrlichia canis and uses thereof”; Inventors: David H. Walker, Jere W. McBride and Xue-jie Yu

BIBLIOGRAPHY:
1. Long S W, Zhang XF, Qi H, Standaert S, Walker DH, Yu XJ: Antigenic variation of Ehrlichia chaffeensis resulting from differential expression of the 28-kDa protein gene family. Infec Immun. 70:1824-1831,2002.

2. Yu X-J, Zhang X-F, McBride JW, Zhang YL, and Walker DH: Phylogenetic relationships of Anaplasma marginale and Ehrlichia platys to other Ehrlichia determined by GroEL amino acid sequences. Int J of Syst Evolution Microbiol. 51:1143-1146, 2001.

3. Moron CG, Bouyer DH, Yu XJ, Foil LD, Crocquet-Valdes, and Walker DH: Phylogenetic analysis of the rompB genes of Rickettsia felis and Rickettsia prowazekii European human and North American flying-squirrel strains. Am. J. Trop. Med. Hyg. 62: 598-603, 2000.

4. McBride JW, Yu X-J, and Walker DH: A conserved transcriptionally active p28 multigene locus of Ehrlichia canis. Gene.254:245-252, 2000.

5. Yu X-J, McBride JW, Zhang, XF, Walker DH. 2000. Characterization of the complete transcriptionally active Ehrlichia chaffeensis 28 kDa outer membrane protein multigene family. Gene. 248:59-68, 2000.

6. Yu X-J, McBride JW, Diaz CM, and Walker DH. Molecular cloning and characterization of the 120-kDa protein gene of Ehrlichia canis and application of the recombinant 120-kDa protein for serodiagnosis of canine ehrlichiosis. J. Clin. Mcrobiol. 38:369-374, 2000.

7. Popov VL, Yu X-J, and Walker DH: The120 kDa outer membrane protein of Ehrlichia chaffeensis: preferential expression on dense-core cells and gene expression in Escherichia coli associated with attachment and entry. Microbial Pathogenesis 28:71-80, 2000.

8. Zhang JZ, Fan MY, Yu X-J, and Raoult D: Phylogenetic analysis of the Chinese Rickettsia isolate BJ-90 [letter]. Emerg.Infect.Dis. 6:432-433, 2000.

9. McBride JW, Yu X-J, and Walker DH: Glycosylation of homologous immunodominant protein of Ehrlichia chaffeensis and Ehrlichia canis. Infect. Immun. 68:13-18, 2000.

10. Yu X-J, Crocquet-Valdes PA, Cullman LC, Popov VL, and Walker DH. Comparison of Ehrlichia chaffeensis recombinant proteins for diagnosis of human monocytotropic ehrlichiosis. J. Clin. Microbiol. 37: 2568–2575, 1999.

11. McBride JW, Yu X-J, Walker DH: Molecular cloning of a conserved major immunoreactive 28-kilodalton protein gene of Ehrlichia canis: a potential serodiagnostic antigen. Clin Diagn Lab Immunol 6:392-399, 1999.

12. Yu X-J, McBride JW, Walker DH: Genetic diversity of the 28-kilodalton outer membrane protein of human isolates of Ehrlichia chaffeensis. J Clin Microbiol 37:1137-1143, 1999.

13. Sexton DJ, Corey GR, Carpenter C, Kong LQ, Gandhi T, Breitschwerdt E, Hegarty B, Chen S-M, Feng H-M, Yu X-J, Olano J, Walker DH, Dumler JS: Dual infection with Ehrlichia chaffeensis and a spotted fever group rickettsia: A case report. Emerg Infect Dis 4:311-316, 1998.

14. Billings AN, Yu X-J, Teel PD, Walker DH: Detection of a spotted fever group rickettsia in Amblyomma cajennense (Acari: Ixodidae) in south Texas. J Med Entomol 35:474-478, 1998.

15. Yu X-J, Walker DH: Sequence and characterization of an Ehrlichia chaffeensis gene encoding 314 amino acids highly homologous to the NAD A enzyme. FEMS Letters 154:53-58, 1997.

16. Yu X-J, Piesman JF, Olson JG, Walker DH: Geographic distribution of different genetic types of Ehrlichia chaffeensis. Am J Trop Med Hyg 56:679-680, 1997.

17. Chen S-M, Yu X-J, Popov VL, Westerman EL, Hamilton FG, Walker DH: Genetic and antigenic diversity of Ehrlichia chaffeensis: comparative analysis of a novel human strain from Oklahoma and previously isolated strains. J Infect Dis 175:856-863, 1997.

18. Yu X-J, Crocquet-Valdes PA, Cullman LC, Walker DH: Cloning and sequencing of the gene for a 120-kDa immunodominant surface protein of Ehrlichia chaffeensis. Gene 184:149-154, 1997.

19. Yu X-J, Crocquet-Valdes P, Cullman LC, Walker DH: The recombinant 120-kDa protein of Ehrlichia chaffeensis, a potential diagnostic tool. J Clin Microbiol 34:2853-2855, 1996.

20. Zavala-Velazquez JE, Yu X-J, Walker DH: Unrecognized spotted fever group rickettsiosis masquerading as dengue fever in Mexico. Am J Trop Med Hyg 55:157-159, 1996.

21. Yu X-J, Raoult D: Monoclonal antibodies to Afipia felis-a putative agent of cat scratch disease. Am J Clin Pathol 101:603-606, 1994.

22. Yu X-J, Raoult D: Serotyping Coxiella burnetii isolates from acute and chronic Q fever patients by using monoclonal antibodies. FEMS Microbiol Letters 117:15-20, 1994.

23. Eremeeva M, Yu X-J, Raoult D: Differentiation among spotted fever group rickettsiae species by analysis of restriction length polymorphism of PCR-amplified DNA. J Clin Microbiol 32:803-810, 1994.

24. Yu X-J, Brouqui P, Dumler JS, Raoult D: Detection of Ehrlichia chaffeensis in human tissue by using a speceis-specific monoclonal antibody. J Clin Microbiol 31:3284-3288, 1993.

25. Yu X-J, Jin Y, Fan MY, Xu GM, Liu QH, Raoult D. Genotypic and antigenic identificaiton of two new strains of spotted fever group rickettsiae isolated from China. J Clin Microbiol 31:83-88, 1993.

26. Walker DH, Liu QH, Yu X-J, Li H, Taylor C, Feng HM: Antigenic diversity of Rickettsia conorii. Am J Trop Med Hyg 47:78-86, 1992.

27. Piao CG, Yu X-J, Fan MY. Serological evidence of Rickettsia tsutsugamushi infection in Northeastern China. Chinese J Zoonosis 8:34-35, 1992

28. Yu X-J, Fan MY, Bi DZ, Xu GM. Antigenic analysis of Chinese strains of spotted fever group rickettsiae with monoclonal antibodies by immunoblotting. Chinese J Microbiol Immun 10:260-261, 1990.

29. Yu X-J, Walker DH, Jerrells TR: Polypeptides constituting the antigenic basis for identification of Rickettsia sibirica species by the standard serotyping method for spotted fever group rickettsiae. Acta Virol 34:71-79, 1990.

30. Bi DZ, Fan MY, Yu X-J. Isolation and identification of the W-88 strain of spotted fever group rickettsiae from a human case in Tongliao City, Inner Mongolia. Chinese J Epidemiology 11:221-225, 1989.

31. Uchida T, Yu X-J, Uchiyama T, Walker DH: Identification of a unique spotted fever group rickettsia from humans in Japan. J Infect Dis 159:1122-1126, 1989.

32. Fan M-Y, Yu X-J, Walker DH: Antigenic analysis of Chinese strains of spotted fever group rickettsiae by protein immunoblotting. Am J Trop Med Hyg 39:497-501, 1988.

BOOK CHAPTERS:
1. Yu X-J, McBride JW, Walker DH: Characterization of the genus-common outer membrane proteins in Ehrlichia. In: Rickettsial and Rickettsial Diseases at the Turn of the Third Millenium. Raoult R, Brouqui P, eds. Elsevier, Paris, France, 103-107, 1999.

2. McBride JW, Yu X-J, Walker DH: Molecular characterization of anew 28-kilodalton protein gene and a multigene locus encoding five homologous 28-kilodalton immunodominant outer membrane proteins of Ehrlichia canis. In: Rickettsial and Rickettsial Diseases at the Turn of the Third Millenium. Raoult R, Brouqui P, eds. Elsevier, Paris, France, 43-47, 1999.

3. Moron, CG, Yu X-J, Crocquet-Valdes PA, and Walker DH: Sequence analysis of the rompB gene of Rickettsia prowazekii isolated from flying seuirrels. In: Rickettsial and Rickettsial Diseases at the Turn of the Third Millenium. Raoult R, Brouqui P, eds. Elsevier, Paris, France, 43-47, 1999.

4. Yu X-J, Crocquet-Valdes P, Cullman LC, Piesman JF, Olson JG, Walker DH: Genetic diversity of a 120-kDa immunodominant protein of Ehrlichia chaffeensis: a potential recombinant diagnostic tool. In: Rickettsiae and Rickettsial Diseases. Kazar J, Toman R, eds. Publishing House of the Slovak Academy of Sciences, Bratislava, Slovak Republic, 324-328, 1996.

5. Uchida T, Uchiyama T, Koyama AH, Yu X-J, Walker DH, Funato T, Kitamura Y: Isolation and identification of Rickettsia japonica, causative agent of spotted fever group rickettsial infections in Japan. In: Rickettsiae and Rickettsial Diseases. Kazar J, Raoult D, eds. Publishing House of the Slovak Academy of Sciences, Bratislava, Slovak Republic, 389-395, 1991.