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舒肝宁治疗化疗药物所致肝损伤的临床疗效观察
【作者】 魏阳； 姚文秀； 周行； 王理杨； 谢华； 赵新；
【Author】 WEI Yang, YAO Wen-xiu, ZHOU Hang, WANG Li-yang, XIE Hua, ZHAO Xin (Department of Medicine, Sichuan Cancer Hospital, Chengdu 610041, China)
【机构】 四川省肿瘤医院内科；
【摘要】 目的观察舒肝宁注射液治疗患者化疗药物所致轻度肝损伤的临床疗效。方法将化疗后有轻度肝损伤的46例恶性肿瘤患者随机分为治疗组和对照组。治疗组26例,患者化疗后静脉输注舒肝宁注射液,每日1次,连续治疗10天。对照组20例,未静脉输注舒肝宁注射液,采用常规口服保肝药治疗。观察两组治疗前后丙氨酸氨基转移酶(ALT)及总胆红素(TBil)的变化及疗效差别。结果治疗后治疗组的ALT显著低于治疗前,其疗效和肝脏功能改善均优于对照组,差异有统计学意义(P<0.05)。结论舒肝宁注射液治疗化疗药物所致轻度肝损伤疗效明显,具有较强的保肝护肝作用。 更多还原
【Abstract】 Objective To observe the protective effectiveness of Shuganning injection on hepatic injury caused by chemotherapy drug. Methods Total of 46 patients with tumors who had slight hepatic injury after chemotherapy were randomly divided into treatment group and control group. In treatment group, Shuganning was additionally added by intravenous infusion to 26 patients. However, the other 20 patients in control group were given routine liver-protective drugs only. The change of ALT was researched before and after therapy to test the effectiveness of Shuganning injection. Results The serum level of ALT in treatment group was obviously lower than that of control group, the difference was significant (P < 0.05). Conclusions Shuganning injection has noticeable effect to relieve hepatic injury caused by chemotherapy.
