Harris: Kelley's Textbook of Rheumatology, 7th ed
Preface
Twenty-three years have passed since Bill Kelley, Clem Sledge, Shaun Ruddy, and I met with Jack Hanley at W.B. Saunders to plan production of The Textbook of Rheumatology. Our goal was to equal or better any current text that described clinical entities and their treatment, but to exceed by far the depth and breadth of existing text in the detail and explication of basic sciences that provide the infrastructure of rheumatology and orthopedic surgery. That first edition, thanks to the diligent writing of many contributors, exceeded our expectations. It became the best-seller of rheumatology texts.
The template for that first edition proved successful, and there has been no reason to change it for subsequent editions. When Bill Kelley stepped down as an active editor, we recognized the importance of "name recognition" and kept the title as Kelley's Textbook of Rheumatology while adding John Sergent and Ralph Budd as associate editors in the sixth edition published in 2001. Recognizing as well the reality that new and younger minds should be involved for the present as well as future editions, this seventh edition has seven editors. We added Gary Firestein and Mark Genovese to the group, and the result is highly amplified brain power. Supplementing Shaun, and Ted, and Clem is the basic science knowledge of Gary and Ralph and the clinical science backgrounds of John and Mark. The future of Kelley's Textbook of Rheumatology is secure.
This seventh edition was planned with full awareness that we are in the midst of remarkable change in the sciences that form the base of rheumatology. Over the past 70 years we have seen the birth and growth of immunology, biochemistry, cell biology, and genetics. Each of these specialities grew with remarkable independence from the others until recent years. The future of our specialty is now intimately associated with integrative science. Recombinant technology now links genetics with biochemistry, and more important, the translational science that has evolved often enables us to leapfrog directly over traditional basic science to understanding of clinical disease states. Just as in neurobiology, where studies of the basis of consciousness involve psychology, philosophy, mathematics, and computer science, the unraveling of complex diseases such as systemic lupus erythematosus will require collaborative ventures by immunologists, immunogeneticists, biochemists, and cell biologists. Ironically, each of these specialists is using the same molecular tools, and so added to the team must be those who are developing the next methods that will supplant the micro-arrays, Western and Southern blots, and knock-out mice.
It is with the likelihood that this integrative collaboration that can bring true synergism to the understanding of rheumatic disease that this edition of Kelley's Textbook of Rheumatology has been planned. Each of the chapters in the section on the basic sciences describes well both the present and future opportunities for application of these specialized data to specific diseases, and each chapter on pathogenesis of specific diseases refers frequently to the advances that science brings to clinical science.
In this seventh edition an accompanying DVD, organized and edited by Shaun Ruddy, provides expansion of clinical photographs, histopathology, and detailed videos of the musculoskeletal system and arthroscopic views of diseased joints.
The corollary of this burst of basic science that can be clearly integrated with clinical science is the need for frequent updates for our readers, updates that fill the gaps between subsequent editions. In response, we are providing "e-ditions" in the format of a web site that will provide every reader with the latest data and their interpretations that will enable basic scientists to plan new experiments, and clinicians to better diagnose and treat their patients.
While we recognize that the future of paper texts is indeterminate amidst the electronic revolution, we are satisfied that this seventh edition of Kelley's Textbook of Rheumatology will serve readers better than any other source of information about rheumatology, orthopedic approaches to rheumatic diseases, and the science that drives understanding of the pathogenesis and treatment of the afflictions that our patients suffer from.
Features
# Full 2 volume set PLUS access to entire contents online - fully searchable.
# Weekly content updates.
# Direct links to PubMed.
# Over 200 additional 4-color images NOT in the book.
# Image library for PowerPoint downloads includes ALL images.
# Self-assessment questions for Board review.
Contents
VOLUME I
Section I: Structure and Function of Bone, Joints, and Connective Tissue
1. Biology of the Normal Joint 2. Collagen and Elastin 3. Matrix Glycoproteins and Proteoglycans in Cartilage 4. Proteinases and Matrix Degradation 5. Muscle: Anatomy, Physiology, and Chemistry 6. Biomechanics of Joints
Section II: Cells Involved in Autoimmune Diseases and Inflammation
7. Antigen Presenting Cells 8. Innate Immunity 9. T Lymphocytes 10. B Cells 11. Synoviocytes 12. Fibroblast Function and Fibrosis 13. Chondrocytes 14. Neutrophils and Eosinophils 15. Platelets and Rheumatic Diseases
Section III: Effector mechanisms in Autoimmunity and Inflammation
16. Autoimmunity 17. Genetics of Rheumatic Diseases 18. Signal Transduction in Rheumatic Diseases 19. Rheumatoid Factor 20. Antinuclear Antibodies 21. Immune Complexes 22. Complement System 23. Prostaglandins, Leukotrienes, and Related Compounds 24. Recruitment of Cells and Angiogenesis 25. Cytokines 26. Apoptosis
Section IV: Broad Issues in the Approach to Rheumatic Diseases
27. Epidemiology of the Rheumatic Diseases 28. Economic Burden of Rheumatic Diseases 29. Assessment of Health Outcomes 30. Development, Execution, and Analysis of Clinical Trials 31. Occupational and Recreational Musculoskeletal Disorders 32. Alternative Care for Arthritis and Related Musculoskeletal Diseases
Section V: Evaluation of Generalized and Localized Symptoms
33. History and Physical Examination of the Musculoskeletal System 34. Monarticular Arthritis 35. Polyarticular Arthritis 36. Fibromyalgia: A Chronic Pain Syndrome 37. Neck Pain 38. Shoulder Pain 39. Low Back Pain 40. Hip and Knee Pain 41. Ankle and Foot Pain 42. Hand and Wrist Pain 43. Temporomandibular Joint Pain 44. The Eye and Rheumatic Disease 45. The Skin and Rheumatic Diseases
Section VI: Diagnostic Tests and Procedures in Rheumatic Diseases
46. Synovial Fluid Analyses, Synovial Biopsy, and Synovial Pathology 47. Arthrocentesis and Injection of Joints and Soft Tissues 48. Arthroscopy 49. Laboratory Evaluation of Inflammatio 50. Biological Markers 51. Imaging of Bones, Joints, and Connective Tissue
Section VII: Modalities of Therapy in Rheumatic Diseases: Non-pharmacologic Interventions
52. Education of Patients 53. Psychosocial Management of the Rheumatic Diseases 54. Nutrition and Rheumatic Diseases 55. Rehabilitation of Patients with Rheumatic Diseases
Section VIII: Drug Therapy for Rheumatic Diseases
56. Nonsteroidal Anti-inflammatory Drugs 57. Glucocorticoid Therapy 58. Second-line Agents: Sulfasalazine, Anti-malarials, Gold Salts, and D-penicillamine 59. Methotrexate, Leflunomide, and Combination Therapies 60. Immunoregulatory Drugs 61. Anti-cytokine Therapies 62. Emerging Therapies 63. Pharmacology and the Elderly 64. Chronic Musculoskeletal Pain
VOLUME 2
Section IX: Rheumatoid Arthritis
65. Etiology and Pathogenesis of Rheumatoid Arthritis 66. Clinical Features of Rheumatoid Arthritis 67. Treatment of Rheumatoid Arthritis 68. Felty’s Syndrome 69. Sjogren’s Syndrome
Section X: Spondyloarthropathies
70. Ankylosing Spondylitis 71. Reiter's Syndrome, Undifferentiated Spondyloarthropathy and Reactive Arthritis 72. Psoriatic Arthritis 73. Enteropathic Arthritis
Section XI: Systemic Lupus Erythematosus and Related Syndromes
74. Pathogenesis of SLE 75. Clinical Manifestations of Systemic Lupus Erythematosus 76. Management of Systemic Lupus Erythematosus 77. Antiphospholipid Antibody Syndrome
Section XII: Mixed Connective Tissue Disease, Scleroderma, and Inflammatory Myopathies
78. Mixed Connective Tissue Disease and Other Overlap Syndromes 79. Scleroderma and Raynaud’s Disease 80. Inflammatory Diseases of Muscle and Other Myopathies
Section XIII: Vasculitis
81. The Classification and Epidemiology of Systemic Vasculitis 82. Giant Cell Arteritis, and Polymyalgia Rheumatica, 83. Anti-Neutrophil Cytoplasmic Antibody (ANCA) Associated Vasculitis: Wegener's Granulomatosis, Microscopic Polyangitis and Churg Strauss Syndrome 84. Polyarteritis and Related Disorders 85. Cutaneous Small-Vessel Vasculitis 86. Behcet’s Disease
Section XIV: Crystal-induced Inflammation
87. Gout and Hyperuricemia 88. Diseases Associated with Articular Deposition of Calcium Pyrophosphate Dihydrate and Basic Calcium Phosphate Crystals
Section XV: Bone, Cartilage, and Heritable Connective Tissue Disorders
89. Biology, Physiology, and Morphology of Bone 90. Metabolic Bone Disease 91. Pathogenesis of Osteoarthritis 92. Clinical Features of Osteoarthritis 93. Management of Osteoarthritis 94. Relapsing Polychondritis 95. Heritable Disorders of Structural Proteins
Section XVI: Rheumatic Diseases of Childhood
96. Juvenile Rheumatoid Arthritis 97. Systemic Lupus Erythematosus, Juvenile Dermatomyositis, Scleroderma and Vasculitis
Section XVII: Infection and Arthritis
98. Arthritis Caused by Bacteria or Their Components 99. Lyme Disease 100. Mycobacterial and Fungal Infections 101. Rheumatic Manifestations of Human Immunodeficiency Virus Infection 102. Viral Arthritis 103. Acute Rheumatic Fever and Post-Streptoccocal Arthritis
XVIII: Arthritis Accompanying Systemic Diseases
104. Amyloidosis 105. Sarcoidosis 106. Iron Storage Disease 107. Hemophilic Arthropathy 108. Hemoglobinopathies and Arthritis 109. Arthritis Accompanying Endocrine and Metabolic Disorders 110. Hypertrophic Osteoarthropathy 111. Musculoskeletal Syndromes in Malignancy 112. Familial Auto-inflammatory Syndromes
XIX: The Common Ground of Rheumatology and Orthopaedic Surgery
113. Tumors and Tumor-like Lesions of Joints 114. Osteonecrosis 115. Introduction to Surgical Management of Patients with Arthritis 116. Principles of Reconstructive Surgery for Arthritis
