魏海明,男,1963年10月出生,山东大学医学院免疫学专业博士毕业,中国科学技术大学生命科学学院教授,研究生导师,中国科学技术大学生命科学实验中心常务副主任,中国科学技术大学实验动物中心主任,中国免疫学会英文会刊Cellular & Molecular Immunology编辑部主任。中国免疫学会终身会员,中国免疫学会青年学术委员会委员,中国抗癌协会肿瘤生物治疗专业委员会委员,主要从事分子免疫学和分子生物学研究。
2002年以来为首承担参加6项科研项目,其中国家863课题1项,国家973课题1项,国家自然科学基金项目2项,国家杰出青年科学基金B类1项(国内负责人),安徽省人才培养及科研带头人专项资金1项。发表SCI论文26篇。
主要发表论文
1.
Haiming Wei, Jian Zhang, Wei Xiao, Jinbo Feng, Rui Sun, and Zhigang Tian. Involvement of Human natural killer (NK) cells in asthma pathogenesis: NK2 cells in type-two cytokine predominance. J Allergy Clin Immunol. 2005 Apr;115(4): 841-7
2.
Haiming Wei, Xiaodong Zheng, Derming Lou, Liang Zhang, Ruijun Zhang, Rui Sun, Zhigang Tian. Tumor-induced suppression of interferon production and enhancement of interleukin-10 production by natural killer (NK) cells:paralleled to CD4+ T cells. Molecular Immunology;2005 May;42(9):1023-31
3.
Zhang B, Wei HM, Zheng XD, Tian ZG. Synthetic short peptides, mimicking MICA and targeting at NKG2D receptors, inhibit the function of human NK cells: implication in therapy of autoimmune liver injury. Peptides ; 2005 Mar;26(3):405-12.
4.
Wei H, Sun R, Xiao W, Feng J, Zhen C, Xu X, Tian Z. Traditional Chinese medicine Astragalus reverses predominance of Th2 cytokines and their up-stream transcript factors in lung cancer patients. Oncol Rep. 2003; 10(5):1507-12
5.
Zhang J, Sun R, Wei HM, Tian Z. Antitumor effects of recombinant human prolactin in human adenocarcinoma-bearing SCID mice with human NK cell xenograft. Int Immunopharmacol. 2005 Feb;5(2):417-25.
6.
Dong ZJ, Wei HM, Sun R, Zhiqiang Hou,Gao B,Tian ZG. Involvement of natural killer cells in Poly IC-induced liver injury. Journal of hepatology;2004; 41(6):966-973(IF=5.3)
7.
Sun R, Wei H, Zhang J, Tian Z. The effects of natural killer-cell depletion on ex vivo expansion of hematopoietic progenitor cells from umbilical cord blood. Haematologica. 2003; 88(5):561-9.
8.
Liu W, Wei H, Liang S, Zhang J, Sun R, Tian Z. A balanced expression of two chains of heterodimer protein, the human interleukin-12, improves high-level expression of the protein in CHO cells. Biochem Biophys Res Commun. 2004; 313(2):287-93.
9.
Liang S, Wei H, Sun R, Tian Z. IFNalpha regulates NK cell cytotoxicity through STAT1 pathway. Cytokine. 2003; 23(6):190-9.
10.
Chen Y, Wei H, Gao B, Hu Z, Zheng S, Tian Z. Activation and function of hepatic NK cells in hepatitis B infection: an underinvestigated innate immune response. J Viral Hepat. 2005 Jan;12(1):38-45.
11.
Wu P, Wei H, Zhang C, Zhang J, Tian Z. Regulation of NK cell activation by stimulatory and inhibitory receptors in tumor escape from innate immunity. Front Biosci. 2005 Sep 1;10:3132-42.
12.
Sun R, Wei H, Zhang J, Li A, Zhang W, Tian Z. Recombinant human prolactin improves antitumor effects of murine natural killer cells in vitro and in vivo.Neuroimmunomodulation. 2002-2003;10(3):169-76.