Br J Cancer. 2010 Aug 31. [Epub ahead of print]
Ubiquitin D is correlated with colon cancer progression and predicts recurrence for stage II-III disease after curative surgery.Yan DW,
Li DW,
Yang YX,
Xia J,
Wang XL,
Zhou CZ,
Fan JW,
Wen YG,
Sun HC,
Wang Q,
Qiu GQ,
Tang HM,
Peng ZH.
Department of General Surgery, Shanghai Jiaotong University Affiliated First People's Hospital, 85 Wujin Road, Shanghai 200080, People's Republic of China.
AbstractBackground:Our recent study observed that the expression of ubiquitin D (UBD), a member of ubiquitin-like modifier family, was upregulated in colon cancer parenchymal cells. The present study further investigated the clinical signicance of UBD in colon cancer.Methods:Using quantitative PCR, tissue microarray (TMA), western blot analysis and immunohistochemical stain, we evaluated UBD mRNA and protein levels in tumour tissues from patients with colon cancer at different stages and in paired adjacent normal epithelium.Results:Immunohistochemical detection of UBD on a TMA containing 203 paired specimens showed that increased cytoplasmic UBD was signicantly associated with depth of cancer invasion, lymph node metastasis, distant metastasis, tumour histologic grade, advanced clinical stage and Ki-67 proliferative index. Patients with UBD-positive tumours had a significantly higher disease recurrence rate and poorer survival than patients with UBD-negative tumours after the radical surgery. Stratification analysis according to tumour stage revealed UBD as an independent predictor for tumour recurrence in patients with stage II and III tumours.Conclusion:UBD may contribute to the progression of colon carcinogenesis and function as a novel prognostic indicator of forecasting recurrence of stage II and III patients after curative operations.British Journal of Cancer advance online publication, 31 August 2010; doi:10.1038/sj.bjc.6605870
www.bjcancer.com.PMID: 20808312 [PubMed - as supplied by publisher]
