1. Arthritis Rheum. 1990 Oct;33(10):1554-9.
Binding of anti-DNA antibodies and inhibition of glomerulonephritis in MRL-lpr/lpr mice by heparin.（题目） Naparstek Y, Ben-Yehuda A, Madaio MP, Bar-Tana R, Schuger L, Pizov G, Neeman ZV, Cohen IR.Hadassah University Hospital, Jerusalem, Israel.
Comment in:
Arthritis Rheum. 1992 Mar;35(3):367-8.
Heparin was found to inhibit the DNA binding of antibodies eluted from kidneys of
both humans and MRL-lpr/lpr mice with systemic lupus erythematosus. Treatment of
MRL-lpr/lpr mice with low doses of heparin significantly inhibited renal damage.
These results suggest that low-dose heparin might be useful in preventing renal
damage in patients with lupus nephritis.
PMID: 2222535 [PubMed - indexed for MEDLINE]
2. Zhonghua Nei Ke Za Zhi. 1997 Nov;36(11):731-5.
Effects of low-molecular-weight heparin on proliferative glomerulonephritis（题目） [Article in Chinese]Yang X, Chen X, Xu Q.General Hospital of Chinese PLA, Beijing.
To investigate the effects of LMWH on proliferative nephritis, we randomized 41
patients who had obvious mesangial cell proliferation testified by renal biopsy
into 2 groups according to age, course, clinical manifestations and the
pathological lesions. The patients in the control group were given steroid,
cyclophosphamide and bennazipril, and the patients in the treated group LMWH
(fraxiparin) with the dosage of 60 anti Xa IU.kg-1.day-1 besides the medicine
used in the control group. We observed a significant decrease in proteinuria and
increase in serum albumin in the treated group compared with those in the control
group after 4 weeks of treatment (P < 0.05). The improvement of creatinine
clearance in the treated group was significant after 8 and 12 weeks treatment
compared with that in the control group (P < 0.05). Our data indicated that LMWH
can decrease the proteinuria in the patients who have intraglomerular coagulation
and proliferative nephritis with various degrees of sclerosis, and it is helpful
to relieve nephrotic syndrome. Because the less risk of hemorrhage, LMWH can be
used for long-term treatment to prevent glomerulosclerosis and the process of
renal function loss without special mornitoring.
PMID: 10451943 [PubMed - indexed for MEDLINE]
重谢~~
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