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还是游客 2008-07-21 19:54

求助  哪位大侠帮忙翻译一下啊(送花 送花}

COMPOSITION:
Each 1 mL contains 10 mg furosemide

PHARMACOLOGICAL CLASSIFICATION:
A 18.1 Diuretics.

PHARMACOLOGICAL ACTION:
Furosemide is a high-ceiling diuretic acting primarily by inhibiting electrolyte and fluid reabsorption in the thick ascending limb of the Loop of Henle as well as in the proximal tubule. It is approximately 90% protein bound, has a half life of about 1 - 2 hours and has a duration of action in the range of 3 - 6 hours. It is excreted mainly by the kidneys and liver and the remainder in the faeces. The excretion of potassium, titratible acid, ammonia, calcium and magnesium are enhanced and the concentration of uric acid in plasma is increased.
In patients with pulmonary oedema, venous capacitance is increased, thereby decreasing left ventricular filling pressure.

INDICATIONS:
Cardiac oedema: All forms of cardiac oedema in conjunction with adequate glycoside therapy.
Ascites due to cirrhosis of the liver, mechanical obstruction or cardiac failure.
Renal oedema (in nephrotic syndrome usually in conjunction with ACTH or corticosteroids).
Pulmonary oedema.
Cerebral oedema.
Forced diuresis e.g. management of barbiturate poisoning.
Burns: to reduce local oedema and to prevent oliguria from progressing to complete anuria.

CONTRA-INDICATIONS:
Patients who are hypersensitive to furosemide or sulphonamides.
Increased azotaemia and oliguria occurring during treatment of severe progressive renal disease – the drug should be discontinued. In hepatic coma and in states of electrolyte depletion, hypovolaemia and hypotension, therapy with Furosemide Injection should not be instituted until the basic condition is corrected or improved.
Lactating women.

WARNINGS:
Fluid and electrolyte imbalance should be monitored during therapy.

DOSAGE AND DIRECTIONS FOR USE:
Intravenous or intramuscular administration of furosemide is indicated in all cases where intestinal absorption is impaired or prompt diuresis is required. The rapid and powerful effect produced by intravenous injection may result in a transitory fall in plasma volume.
Intravenous injection should be given slowly (over 1 to 2 minutes).

The recommended adult dose by this route is 20 to 40 mg, repeated if necessary after not less than 2 hours. The usual pediatric dose is 1 mg/kg.

Pulmonary oedema: Initial dose 40 mg intravenously. If necessary, the injection may be repeated after approximately 60 to 90 minutes.

SIDE-EFFECTS AND SPECIAL PRECAUTIONS:
With parenteral use of furosemide in high doses reversible deafness and tinnitus have been reported when the infusion is faster than 4 mg per minute. Permanent deafness may develop in patients with impaired renal function.
Various forms of skin reactions including rashes, urticaria, exfoliative dermatitis, paraesthesia, pruritis, purpura, photosensitivity and erythema multiforme may occur.
Nausea, vomiting, diarrhoea, blurred vision, dizziness, headache, pancreatitis, muscle spasm, cramps, hypotension and allergic reactions may occur.
Furosemide should be used with care in patients with prostatic hypertrophy or impairment of micturition.
Anaemia, leucopenia, agranulocytosis, aplastic anaemia and thrombocytopenia (with purpura) may occur.
Asymptomatic hyperuricaemia may occur and gout may be precipitated.
Alterations in glucose tolerance tests with abnormalities of the fasting and 2-hour postprandial sugar levels have been observed, and cases of precipitation of diabetes mellitus have been reported.
Furosemide increases urinary excretion of calcium, may lower serum calcium levels and cases of tetany have been reported.
Excessive diuresis may result in dehydration and reduction in blood volume, with circulatory collapse and with the possibility of vascular thrombosis and embolism, particularly in elderly patients. Excessive loss of potassium in patients receiving cardiac glycosides may precipitate digitalis toxicity. Care should also be taken in patients receiving potassium-depleting steroids.
Electrolyte disturbances: Hypokalaemia may be counteracted with a potassium-rich diet. If a deficiency state exists - especially in cirrhosis - the serum potassium must first be restored by potassium supplementation, and if necessary, sodium and chloride. Because of the strong natriuretic effect of Furosemide injection, the sodium levels could be reduced especially if the oedema is reduced quickly. Magnesium depletion may develop. Electrolyte depletion may present as weakness, dizziness, lethargy, cramps in the legs, loss of appetite, vomiting and/or mental confusion.
The safety of furosemide in pregnancy has not been established.
Nephrotoxicity associated with the use of cephalosporins and aminoglycosides may be potentiated when furosemide is used in conjunction with cephalosporins and aminoglycosides. These medicines should thus not be used together.
Liver damage or dysfunction as well as reversible renal failure have been reported. Furosemide should be used with caution in patients with impaired hepatic or renal function, or with diabetes mellitus or adrenal disease.
Furosemide may enhance the neuromuscular blocking action of non-depolarising muscle relaxants, such as tubocurarine, as well as the effects of guanethidine, methyldopa and rauwolfia alkaloids.
Postural hypotension associated with Furosemide may be enhanced by concomitant ingestion of alcohol, barbiturates or narcotics.
Concomitant administration of furosemide and lithium may lead to toxic blood concentrations of lithium.
Cross sensitivity may occur with furosemide and sulfonamides.

KNOWN SYMPTOMS OF OVERDOSAGE AND PARTICULARS OF ITS TREATMENT:
After the ingestion of an overdose there is some danger of dehydration and electrolyte depletion due to excessive diuresis.
The guiding principle of treatment is water and electrolyte replacement in accordance with urine output (with monitoring of carbohydrate metabolism if necessary). If difficulty in micturition is proved or suspected as in cases of prostatic hypertrophy or impairment of consciousness, care must be taken to ensure a free outflow of urine from the bladder.
Treatment is symptomatic and supportive.

IDENTIFICATION:
A clear colourless solution in 2 mL amber ampoules and 5 mL clear ampoules.

PRESENTATION:
2 mL amber or 5 mL clear ampoules packed in containers of 10.

STORAGE INSTRUCTIONS:
Protect from light. Store below 25°C.
KEEP OUT OF REACH OF CHILDREN.

会飞的企鹅 2008-07-21 20:38
天呢。现在看到e文就头疼……

han25 2008-07-21 21:39
不就是速尿的说明书么?
换个英文就不认识了?
自己去网上搜个中文的就是了
搜呋塞米也行啊

han25 2008-07-21 21:40
哎,楼主的那个级别,能送花么?

lanhu4977 2008-07-21 22:07
还是上丁香园上求助吧,快且准确。

我的九月 2008-07-21 22:07
组成:
每个1毫升含有10毫克速尿

药理分类:
1 1月18日利尿剂。

药理作用:
呋塞米是一个高的上限,利尿代理,主要是通过抑制电解质和液体重吸收,在厚厚的升序肢体的回路亨勒,以及在肾小管上皮。这是大约90 %的蛋白质的约束,有一个半衰期约1 -2小时,有时间采取行动的范围, 3 - 6个小时。这是排泄的主要是由肾脏和肝脏,其余的在粪便中。排泄钾, titratible酸,氨,钙和镁是加强和浓度的尿酸在血浆中是有所增加。
在病人的肺水肿,静脉电容增加,从而减少左室充盈的压力。

迹象显示:
心脏水肿:一切形式的心脏水肿在与足够的苷治疗。
肝硬化腹水的肝,机械阻塞或心脏衰竭。
肾水肿(肾病综合征患者通常在与促肾上腺皮质激素或类固醇) 。
肺水肿。
脑水肿。
强迫利尿,例如管理巴比妥中毒。
烧伤:以减少当地的水肿,并防止少尿从进展,以完成无尿。

孔特拉的禁忌:
谁是病人的过敏性,以速尿或sulphonamides 。
增加azotaemia和少尿期间发生的治疗重症逐步肾脏疾病-药物应予停止。在肝昏迷,并在国家电解质枯竭, hypovolaemia和低血压,治疗与呋塞米注射液不应该提起,直到基本条件是纠正或改善。
哺乳期妇女。

警告:
流体和电解质不平衡,应该监测在治疗过程中。

剂量和方向,使用说明:
静脉或肌肉注射,政府当局速尿是表示,在所有情况下,肠道吸收受损或提示利尿是必需的。快速和强大的影响所产生的静脉注射可能会导致在一个短暂的下降,血浆量。
静脉注射应给予缓慢(超过1至2分钟) 。

推荐成人剂量,由这条路线是20至40毫克,反复后,如有必要,不得少于2个小时。一般小儿剂量是1毫克/公斤。

肺水肿:起始剂量40毫克静脉注射。如果有必要,注射可能会重复后,大约60至90分钟。

副作用和特别的预防措施:
与肠外使用速尿高剂量的可逆耳聋和耳鸣已报告时,输液速度较快,超过4毫克每分钟。永久失聪的可能发展,患者肾功能受损。
各种形式的皮肤反应,包括皮疹,荨麻疹,剥脱性皮炎, paraesthesia , pruritis ,紫癜,光敏性和多形性红斑,可能会发生。
恶心,呕吐,腹泻,视力模糊,头晕,头痛,胰腺炎,肌肉痉挛,痉挛,低血压和过敏反应,可能会发生。
速尿应小心使用,在病人与前列腺增生症或减值的排尿。
贫血,白血球减少,粒细胞缺乏症,再生障碍性贫血和血小板减少(与性紫癜) ,可能会发生。
无症状高尿酸血症,可能会发生与痛风的可能沉淀。
改建在葡萄糖耐量试验异常,空腹和2小时餐后血糖水平已观察到,和案件降水糖尿病已报告。
速尿增加尿中钙,可降低血清钙水平和案件手足搐搦已报告。
过度利尿可能会导致脱水和减少在血容量,与循环系统崩溃的可能性与血管血栓和栓塞,特别是在老年患者。过多的损失中钾的病人接受心苷可能沉淀洋地黄毒性。护理也应考虑在病人接受钾枯竭的类固醇。
电解质的干扰: hypokalaemia可能会抵消与富钾的饮食习惯。如果一个国家存在的不足-尤其是在肝硬化-血清钾,必须先恢复钾的补充,如果有必要,钠和氯离子。由于强烈的钠的作用,呋塞米注射液,钠水平可以减少,尤其是如果水肿是减少很快。镁耗竭可能发展。电解质耗竭,可能目前的弱点,晕眩,嗜睡,抽筋,在腿部,食欲不振,呕吐和/或精神混乱。
安全速尿在妊娠尚未建立。
肾毒性与使用头孢菌素类和氨基糖苷类可能potentiated时,呋塞米是用在与头孢菌素类和氨基糖苷类。这些药物应,因此不能一起使用。
肝损伤或功能障碍,以及可逆的肾功能衰竭已报告。速尿应谨慎使用在患者受损的肝或肾功能,或与糖尿病或肾上腺疾病。
速尿,可以提高神经肌肉阻断行动的非depolarising肌肉松弛剂,如tubocurarine ,以及影响guanethidine ,甲基和rauwolfia生物碱。
姿势性低血压与速尿可增强相伴的摄取酒精,巴比妥类或麻醉品。
伴随政府速尿和锂可能导致有毒的血药浓度的锂。
两岸关系的敏感性,可能会发生与速尿和磺胺类药物。

众所周知,过量的症状和细节的处理:
后,摄入过量是有一定的危险性脱水及电解质耗竭因过度利尿。
指导原则的治疗是水和电解质取代,根据尿量(与监测碳水化合物代谢,如果必要的话) 。如果在排尿困难的证明或怀疑,因为在案件前列腺肥大或减值的意识,护理必须采取措施,以确保一个自由流出的尿液从膀胱。
治疗缓解症状和辅助性。

鉴定:
一个清晰的无色溶液在二毫升黄色安瓿和5毫升明确的安瓿。

介绍:
二毫升黄色或五毫升明确的安瓿装载于集装箱内的10 。

存储说明:
保护轻。商店低于25 ° C时
继续走出达成的儿童。

我的九月 2008-07-21 22:08
google的在线翻译,剩下的自己润色


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