陈子江 ， 女， 1959 年 10 月 07 日生人，医学博士，留美博士后。
专业 ： 生殖医学，妇科内分泌学，生殖遗传学。
专业技术职务： 教授，主任医师
通讯地址：济南市经五纬七路 324 号，山东省立医院生殖医学中心， 250021
E-mail ：
zjchen59@yahoo.com 办公室电话： 0531-87068226 传真 ： 0 531-87068226
一、 现任职
山东大学医学院 副院长， 关键岗位教授，博士生导师
山东省立医院 副院长
山东省立医院妇产科 主任，主任医师
山东大学生殖医学研究中心 主任
山东大学干细胞研究所 所长
山东省生殖医学重点实验室 主任 首席专家
二、学术及社会任职
第十、十一届全国政协委员
山东省第十、十一届人大常委
中国科学技术协会全国委员会 委员
中华医学会全国理事会 理事
中国女医师协会全国理事会 理事
中华医学会妇产科学分会委员会 委员
全国妇科生殖内分泌学组 副组长
山东省医学会生殖医学分会 主任委员
世界生殖医学会理事会 理事
欧洲人类生殖医学与胚胎学协会 会员
美国生殖医学会 会员
《 Fertility and Sterility 》中文版 副主编
《中华妇产科杂志》等国内外十余家杂志的编委及常务编委
三、科研成果奖励：
曾获国家发明三等奖（第二位），山东省十大科技成果奖（第一位），山东省科技进步一等奖（第一位），教育部提名国家科技进步一等奖（第一位），山东省科技进步二等奖（第一位）等十余项科研奖励。此外， 2006 年获 2 项实用新型专利。
四、荣誉
曾获国家教委“霍英东基金会”研究类奖，卫生部“吴阶平医学奖”，“第二届全国中青年医学科技之星”奖，“全国优秀科技工作者”称号， 全国“三八”红旗手标兵称号 ， 全国“五一”劳动奖章等三十余项荣誉。
五、工作经历
1979.08-1984.07 山东医学院医疗系本科
1984.08-1987.07 山东医学院妇产科硕士研究生
1987.08-1989.12 山东医科大学妇产科博士研究生
1989.12-1993.06 山东医科大学讲师，山东省立医院妇科主治医师
1993.07- 今 山东大学医学院教授，山东省立医院妇产科主任医师
1996.09-1996.12 美国 CLEVELAND CLINIC FOUNDATION 特邀国际访问学者
1996.12-1998.12 美国 CWRU 医学院博士后
1999.01-2005.06 研究员 Department of Medicine,
Case Western Reserve University, School of Medicine. USA
2000.10- 今 博士生导师
2005.07- 今 （兼职） Research Assisted Professor,
University of Missouri, Medical School. USA
六、截至 2008 年 6 月共发表学术论文 240 篇， SCI 论文 40 篇（目录如下）：
． Yuhua Shi, Xuan Gao, Xuedong Sun, Peng Zhang, Zi-Jiang Chen * . Clinical and metabolic characteristics of Polycystic Ovary Syndrome without polycystic Ovary: a pilot study on Chinese women. Fertility and Sterility. 2007 Sep 21. [Epub ahead of print] (IF:3.28)
． Kehua Wang, Li You, Yuhua Shi, Laicheng Wang, Meixin Zhang, Zi-Jiang Chen * . Association of genetic variants of Insulin degrading enzyme with metabolic features in women with polycystic ovary syndrome. Fertility and Sterility. 2007 Oct 20. [Epub ahead of print] (IF:3.28)
． Lu S , Zhao Y , Hu J , Li X , Zhang H , You L , Chen ZJ * . Combined use of phosphodiesterase-5 inhibitors and selective serotonin reuptake inhibitors for temporary ejaculation failure in couple undergoing assisted reproductive technologies. Fertility and Sterility. 2008 Apr 26. [Epub ahead of print] (IF:3.28)
． Jiao YL, Ma CY, Wang LC, Cui B, Zhang J, You L, Chen ZJ, Li JF, Zhao YR * . Polymorphisms of KIRs Gene and HLA-C Alleles in Patients with Ankylosing Spondylitis: Possible Association with Susceptibility to the Disease. J Clin Immunol. 2008 Feb 23. [Epub ahead of print] (IF:2.75)
． Han Zhao, Zi-Jiang Chen ( Co-first authors) , Yuhua Shi, Yingying Qin, Shan Wang, Joe Leigh Simpson and Aleksandar Rajkovic. Transcription Factor FIGLA is Mutated in Patients with Premature Ovarian Failure. Am J Hum Genet. 2 008 ; 82(6):1342-1348. (IF:12.63)
． Haobo Zhang, Zi-Jiang Chen * . Early apoptotic changes in human spermatozoa and their relationships with conventional semen parameters and sperm DNA fragmentation. Asia Journal of Andrology. 2008; 10(2): 227-235. (IF:1.74)
． Ning Zhang, Yu-Hua Shi, Cui-Fang Hao, Harvest F Gu, Yuan Li, Yue-Ran Zhao, Lai-Cheng Wang and Zi-Jiang Chen* . Association of + 45G 15G (T/G) and +276(G/T) polymorphisms in the ADIPOQ gene with polycystic ovary syndrome among Han Chinese women. European Journal of Endocrinology. 2008; 158 (2): 255-60 . ( IF 3.15)
． Qin Y , Zhao H , Kovanci E , Simpson JL , Zi-Jiang Chen , Rajkovic A . Analysis of LHX8 mutation in premature ovarian failure. Fertility and Sterility. 2008; 89(4): 1012-1014. (IF:3.28)
． Steven F. Mullen, Mei Li, Yuan Li, Zi-Jiang Chen and John K. Critser. Human oocyte vitrification: the permeability of metaphase II oocytes to water and ethylene glycol and the appliance toward vitrification. Fertility and Sterility. 2008; 89(6): 1812-1825. (IF:3.28)
． Peng Zhang, Yu-hua Shi, Lai-cheng Wang, Zi-Jiang Chen * . Sequence variants in exons of the BMP-15 gene in Chinese patients with Premature Ovarian Failure. Acta Obstet Gynecol Scand. 2007; 86 (5): 585-589. (IF:1.33)
． Shan Wang, Yueran Zhao, Yulian Jiao , Laicheng Wang , Jianfeng Li, Bin Cui, Chengyan Xu, Yuhua Shi, Zi-Jiang Chen * . Increased activating killer immunoglobulin-like receptor genes and decreased specific HLA-C alleles in couples with recurrent spontaneous abortion. Biochem Biophys Res Commun. 2007; 360 (3): 696-701. (IF:2.86)
． Yingying Qin, Youngsok Choi, Han Zhao, Joe Leigh Simpson, Zi-Jiang Chen , Aleksandar Rajkovic. NOBOX Homeobox Mutation Causes Premature Ovarian Failure. Am J Hum Genet. 2007; 81 (3): 576-581. (IF:12.63)
． Jinlai Meng, Xietong Wang, Yu Wang, Yafei Yue, Xin Wang, Zi-Jiang Chen * . Use of maternal plasma for non-invasive prenatal diagnosis of fetal ABO genotypes. Clin Chem Lab Med. 2007; 45 (8): 981-986. (IF:1.73)
． Yingying Qin, Han Zhao, Ertug Kovanci, Joe Leigh Simpson, Zi-Jiang Chen* and Aleksandar Rakovic. Mutation analysis of NANOS 3 in 80 Chinese and 88 Caucasian women with premature ovarian failure. Fertility and Sterility. 2007;88(5): 1465-1467. (IF:3.28)
． Han Zhao, Yingying Qin, Ertug Kovanci, Joe Leigh Simpson, Zi-Jiang Chen* , Aleksandar Rakovic. Analyses of GDF9 mutation in 100 Chinese women with premature ovarian failure. Fertility and Sterility. 2007; 88 (5):1474-1476. (IF:3.28)
． Yu Wang, Jin-Lai Meng, Xie-Tong Wang, Yue-Ran Zhao, Lai-Cheng Wang, Joe Leigh Simpson and Zi-Jiang Chen * . Detection of genomic imbalances by comparative genomic hybridization in Chinese fetuses with malformations. Neuroendocrinology Letters. 2007; 28 (4): 406-409. (IF: 0.93)
． Qin Y, Yan J, Simpson JL, Gu HF, Wang LC, Zi-Jiang Chen * . Novel non-synonymous mutation in the transforming growth factor beta binding protein-like (TB) domain of the fibrillin-1 (FBN1) gene in a Han Chinese family with Marfan syndrome (MFS). Neuroendocrinology Letters. 2007; 28(5):629-632. (IF:0.93)
． Peng Zhang, Yuhua Shi, Xuan Gao, Shan Wang, Junchao Wang , Zi-Jiang Chen * . Clinical analysis of Chinese infertility women with premature ovarian failure. Neuroendocrinology Letters. 2007; 28 (5): 580-584 . (IF:0.93)
． Yuhua Shi, Meng Guo, Junhao Yan, Wei Sun, Xiaoli Zhang, Ling Geng, Lihong Xu, Zijiang Chen* . Analysis of clinical characteristics in large-scale chinese women with polycystic ovary syndrome Neuroendocrinology Letters. 2007; 28( 6): 807-810. ( IF: 0.93)
． Yuan Li, Huai-Liang Feng, Steve F Mullen, John Critser, Zi-Jiang Chen * . A confocal microscopy analysis of the spindle and chromosome configurations of human oocytes matured in vitro. Fertility and Sterility. 2006; 85(4): 827-832 (IF:3.17)
． Qun Lu, YR Zhao, Xuan Gao, Yuan Li, SY Ma, Steve Mullen, JK Crister, Zi-Jiang Chen * . Combination of calcium ionophore A23187 with puromycin salvages human unfertilized oocytes after ICSI. European Journal of Obstetrics & Gynecology and Reproductive Biology. 2006; 126:72-76. (IF:1.27)
． Junhao Yan, Huai L Feng, Zi-Jiang Chen * , Jingmei Hu, Xuan Gao, Yingying Qin,Influence of swim-up time on the ratio of X- and Y-bearing spermatozoa. European Journal of Obstetrics & Gynecology and Reproductive Biology. 2006; 129:150-154. (IF:1.27)
． Yuan Li, Steven F. Mullen, John K. Critser, Zi-Jiang Chen * . In vitro oocyte maturation: an important and challenging area for investigation. Fertility and Sterility. 2006;85(4): 841. (IF:3.17)
． Ding, Y, Zi-Jiang Chen , Liu S, Che D, Vetter M.and Chang C-H. Inhibition of Nox-4 activity by plumbagin, a plant-derived bioactive naphthoquinone. J. Pharm. Pharmacol. 2005; 57: 111-116. ( IF:1.40 )
． Zi-Jiang Chen ,Yan Junhao, Feng Huailiang. Aneuploid analysis of tripronuclear zygotes derived from in vitro fertilization and intracytoplasmic sperm injection in humans. Fertility and Sterility. 2005; 83(6): 1845-1848. ( IF:3.17 )
． Zi-Jiang Chen , Mei Li, Yuan Li, Li-Xin Zhao, Rong tang, Yan Sheng, Xuan Gao, Chung-Ho Chang, Huai-liang Feng. Effects of sucrose concentration on the developmental potential of human frozen-thawed oocytes at different stages of maturity. Human Reproduction. 2004; 19 (10): 2345-2349. ( IF:3.37 )
． Rong Tang, Yan Sheng, Zi-Jiang Chen * . Rupture of pregnancy in a communicating rudimentary uterine horn after in vitro fertilization and embryo transfer. Int J Gynecol Obstet. 2004; 86 (3): 394-395. ( IF:0.76 )
． Zi-Jiang Chen , Michael Vetter, Geen-Dong Chang, Danian Che. Cyclophilin A functions as an endogenous inhibitor for membrane-bound guanylate cyclase GC-A. Hypertension. 2004; 44: 963-968. ( IF:5.34 )
． Zi-Jiang Chen , Michael Vetter, Geen-Dong Chang, et al. Quercetin, a phytoestrogen and dietary flavonoid, activates different membrane-bound granylate cyclase isoforms in LLC-PK1 and PC12 cells. Journal of Pharmacy and Pharmacology. 2003; 55: 353-358. ( IF:1.35 )
． Michael Vetter, Zi-Jiang Chen , Geen-Dong chang, Danian Che, Shiguo Liu, Chung-Ho Chang. Cyclosporine-A disrupts bradykinin signaling through superoxide. Hypertension. 2003; 41(5): 1136-1142. ( IF:5.34 )
． Zi-Jiang Chen , Michael Vetter, Geen-Dong chang, Yaxian Ding, Shiguo Liu, Chung-Ho Chang. Non-genomic effects of tamoxifen on the activivation of membrane-bound guanylate cyclase GC-A. J. Pharm. Pharmacol. 2003; 55: 1539-1545. ( IF:1.35 )
． Zi-Jiang Chen , Michael Vetter, Danian Che, Liu S, M Tsai M-L, Chang C-H. The bradykinin/Soluble guanylate cyclase signaling pathway is impaired in androgen-independent prostate cancer cells. Cancer Letter. 2002; 177 (2): 181-187. ( IF:2.94 )
． Zi-Jiang Chen , Danian Che and Chung-Ho. Antioxidants Vitamin C and dithioreitrol activate membrane-bound gunaylate cyclase in PC12 cells. J. Pharmacy & Pharmacology. 2001; 53 (2): 243-247. ( IF:1.22 )
． Zi-Jiang Chen , Chang C-H. Protelytic activation of membrane-bound guanylate cyclase. Biochemical Pharmacology. 2001; 61 (7): 915-920. ( IF:2.98 )
． Zi-Jiang Chen , Danian Che, Michael Vetter, Shiguo Liu, Chung-Ho Chang. 17-Β estradiol inhibits soluble guanylate cyclase activity through a protein tyrosine phosphatase. Journal of Steroid Biochemistry & Molecular Biology. 2001; 78 (5): 451-458( IF:2.55 )
． Zi-Jiang Chen , Da-nian Che, Chung-Ho Chang. Resveratrol activates membrane-bound guanylate cyclase in PC12 cells. Pharma and Pharmacol Commun. 2000; 6: 211-215. ( IF:1.23 )
． Zi-Jiang Chen , Zhen-Hua Miao, Michael Vetter, Nickolai Dulin, Shiguo Liu, Danian Che, Hughes B, Mura F, Douglas J, Chang C-H. Molecular cloning and expression of regulatory protein for membrane-bound guanylate cyclase GC-A. J. Biochem. Biophysic. Res.Commun. 2000; 278 (1): 106-111. ( IF:3.06 )
． Allen D. Seftel, Gregory T. Maclennan, Zi-Jiang Chen , et al. Loss of TGFβ,apoptosis,and Bcl -2 in erectile dysfunction and up-regulation of p53 and HIF-1α in diabetes-associated erecile dysfunction. Molecular Urology, 1999; 3 (2): 103-107. ( IF:0.82 )
． Zi-JiangChen , LindaYu, Chung-Ho Chang. Stimulation of membrane-bound guanylate cyclase activity by 17- b estradiol. Biochem Biophysic. Res. Commun. 1998; 252: 639-642. ( IF:2.78 )
． Ying-Kuan Su, Zi-Jiang Chen , Yun Feng, Lian-Kui Liu, Ji-Jun Li, Xin-Min Liu. Delivery by direct intrauterine transfer of gametes. Chinese Medical Journal. 1992; 105 (9): 785-787.( IF:0.13 )
九、主编专业著作 ：
《多囊卵巢综合征——基础与临床》主编 人民卫生出版社 2008 年
《妇产科及药物治疗学》主编 人民卫生出版社 2006 年
《人类生殖与辅助生殖》主编 科学出版社 2005 年
《妇产科学学习指南》 主编 山东大学出版社 2005 年
《妇产科学》 主编 人民军医出版社 2003 年
《妇产科多选题》 主编 第二军医大学出版社 2003 年
十、科研立项情况：
在研课题 （均为项目负责人）
2003.01-2008.12 人胚胎干细胞建系及诱导分化的研究
山东省科技发展重点项目 20 万
2006.10-2011.10 生殖细胞健康与母胎识别及免疫豁免的分子基础
负责人：生殖干细胞体外操作与辅助生殖新技术
国家重点基础研究发展计划（ 973 项目） 533.63 万
2006.12-2008.12 基因敲除动物异种器官移植和组织器官修复工程技术研究
山东省自主创新重大科技专项 300 万
2007.01-2009.12 雌激素 / 鸟苷酸环化酶 GC-A 非基因作用分子机制
国家自然科学基金 28 万
2007.01-2008.12 人卵深低温冷冻保存技术的研究（首席）
国家高技术研究发展计划（ 863 项目） 345 万
2007.06-2009.06 荧光原位杂交技术在产前遗传性疾病检测中的应用研究
卫生部医药卫生科技发展研究项目 32.5 万
在研课题（ CO-PI ）
2006.04-2009.03 多囊卵巢综合征中的卵泡发育异常研究
中加合作自然科学基金 9 万加元
十一、联合培养情况
与国外联合培养学生 4 人：
． 秦莹莹 美国 贝勒医院
． 赵涵 美国 贝勒医院
． 高姗姗 美国 密苏立大学
． 郭萌 荷兰
Department of Reproductive Medicine and Gynaecology, University Medical Centre
十二、 2009 年拟招收博士研究生数量 ： 3 人
十三、培养的博士生适合从事工作领域 ：医疗卫生、科学研究
